Case Western Reserve University School of Medicine, Cleveland, OH.
Department of Vascular Surgery, Cleveland Clinic Foundation, Cleveland, OH.
J Vasc Surg. 2024 Jan;79(1):44-54. doi: 10.1016/j.jvs.2023.08.127. Epub 2023 Aug 30.
Given the ongoing nature of research in the social determinants space and urges to improve United States Preventive Services Task Force screening efforts for abdominal aortic aneurysms (AAAs), this project aims to characterize the association between the level of socioeconomic deprivation, rurality, and ruptured AAA (rAAA) presentation across the United States.
We queried the Vascular Quality Initiative registry (2010-2019) for patients with AAAs. The area deprivation index (ADI) is an index from 1 to 100 used to capture socioeconomic status. ADI was grouped into quintiles, with the most deprived regions being quintile 5 and having the highest ADI index. Multivariable logistic regression assessed the association between ADI, rurality, and rAAA presentation overall and before age 65.
Of the 82,909 patients included, 11,458 patients (14%) resided in the most socioeconomically deprived regions, and 18,083 patients (22%) lived in rural regions. Overall, 6831 patients (8.2%) experienced an rAAA, with 4696 patients (69%) residing in the three most deprived quintiles. Most patients underwent endovascular repair (n = 67,933; 82%), followed by open repair (n = 14,976; 18%). On multivariable analysis, residence in the most socioeconomically deprived region was associated with a near 1.5-fold increased odds of presenting with an rAAA compared with a residence in the least deprived regions (odds ratio [OR], 1.46; 95% confidence interval [CI], 1.31-1.63; P < .001), whereas urban residence was associated with a decreased odds to present with an rAAA compared with rural residence (OR, 0.84; 95% CI, 0.79-0.89; P < .001). When stratifying the study population by the United States Preventive Services Task Force recommended age for AAA screening (65 years old), 14,147 patients (17%) were under 65. Of those under 65, 1381 patients (9.8%) experienced a rAAA, and 9955 patients (71%) resided in the three most deprived quintiles. Residence in the most socioeconomically deprived region was associated with an increased odds of presenting with an rAAA compared with residence in the least deprived region (OR, 1.31; 95% CI, 1.01-1.69; P = .042). However, there were no significant associations between rural residence and increased rAAA presentation among individuals under 65 (OR, 1.07; 95% CI, 0.93-1.23; P = .36).
Among all patients in this study, patients residing in highly socioeconomically deprived or rural regions were more likely to present with an rAAA, but among those under 65, only residence in a socioeconomically deprived area was associated with increased odds of rAAA presentation. Understanding the effects of socioeconomic deprivation on rAAA presentation can identify at-risk populations for early AAA screening before rupture.
鉴于社会决定因素领域的研究具有持续性,并且迫切需要改进美国预防服务工作组对腹主动脉瘤(AAA)的筛查工作,本项目旨在描述社会经济剥夺程度、农村地区与美国破裂性 AAA(rAAA)表现之间的关联。
我们查询了血管质量倡议登记处(2010-2019 年)中患有 AAA 的患者数据。区域剥夺指数(ADI)是一个 1 到 100 的指数,用于捕捉社会经济地位。ADI 分为五分位数,最贫困的地区为五分位数 5,ADI 指数最高。多变量逻辑回归评估了 ADI、农村地区与 rAAA 总体表现和 65 岁以下表现之间的关联。
在纳入的 82909 名患者中,11458 名患者(14%)居住在最贫困的地区,18083 名患者(22%)居住在农村地区。总体而言,6831 名患者(8.2%)发生 rAAA,其中 4696 名患者(69%)居住在最贫困的三个五分位数中。大多数患者接受了血管内修复(n=67933;82%),其次是开放修复(n=14976;18%)。多变量分析显示,与居住在最不贫困地区的患者相比,居住在最贫困地区的患者 rAAA 表现的可能性增加近 1.5 倍(优势比 [OR],1.46;95%置信区间 [CI],1.31-1.63;P<.001),而与农村地区相比,城市地区的 rAAA 表现可能性降低(OR,0.84;95%CI,0.79-0.89;P<.001)。当按美国预防服务工作组推荐的 AAA 筛查年龄(65 岁)对研究人群进行分层时,14147 名患者(17%)年龄小于 65 岁。在这些年龄小于 65 岁的患者中,1381 名患者(9.8%)发生 rAAA,9955 名患者(71%)居住在最贫困的三个五分位数中。与居住在最贫困地区的患者相比,居住在最贫困地区的患者 rAAA 表现的可能性增加(OR,1.31;95%CI,1.01-1.69;P=0.042)。然而,在年龄小于 65 岁的患者中,农村地区与 rAAA 表现增加之间没有显著关联(OR,1.07;95%CI,0.93-1.23;P=0.36)。
在本研究的所有患者中,居住在高度社会经济贫困或农村地区的患者更有可能出现 rAAA,但在年龄小于 65 岁的患者中,只有居住在社会经济贫困地区与 rAAA 表现增加的可能性相关。了解社会经济剥夺对 rAAA 表现的影响可以识别高危人群,以便在破裂前进行早期 AAA 筛查。