Key Laboratory of Precision Nutrition and Food Quality, Beijing Laboratory for Food Quality and Safety, Department of Nutrition and Health, China Agricultural University, Beijing, 100191, China.
Small. 2024 Jan;20(2):e2304852. doi: 10.1002/smll.202304852. Epub 2023 Sep 1.
Riboswitches have received significant attention over the last two decades for their multiple functionalities and great potential for applications in various fields. This article highlights and reviews the recent advances in biosensing and biotherapy. These fields involve a wide range of applications, such as food safety detection, environmental monitoring, metabolic engineering, live cell imaging, wearable biosensors, antibacterial drug targets, and gene therapy. The discovery, origin, and optimization of riboswitches are summarized to help readers better understand their multidimensional applications. Finally, this review discusses the multidimensional challenges and development of riboswitches in order to further expand their potential for novel applications.
在过去的二十年中，核糖开关因其多种功能和在各个领域应用的巨大潜力而受到了广泛关注。本文重点介绍和回顾了生物传感和生物治疗领域的最新进展。这些领域涉及广泛的应用，如食品安全检测、环境监测、代谢工程、活细胞成像、可穿戴生物传感器、抗菌药物靶点和基因治疗。本文总结了核糖开关的发现、起源和优化，以帮助读者更好地理解其多维应用。最后，本文讨论了核糖开关面临的多维挑战和发展，以进一步拓展其在新应用中的潜力。
