Veterinary Specialty Hospital by Ethos Veterinary Health, San Diego, California, USA.
Advanced Extracorporeal and Urinary Disease Service, UC Veterinary Medical Center-San Diego, San Diego, California, USA.
Vet Med Sci. 2023 Nov;9(6):2438-2442. doi: 10.1002/vms3.1253. Epub 2023 Sep 2.
To describe a case of 5-hydroxytryptophan (5-HTP) toxicity successfully treated with haemodialysis in a dog.
A 3-year-old, male neutered Labrador Retriever, weighing 28.2 kg, presented to the emergency department approximately 4-5 h after ingesting a human supplement containing 200 mg of 5-HTP. The amount of 5-HTP ingested was estimated between 980 and 1988 mg (35-71 mg/kg). At presentation, the dog demonstrated progressive neurologic abnormalities consistent with serotonin syndrome, including altered mentation and ataxia. Due to the magnitude of the ingested dose and progression of clinical signs, extracorporeal blood purification with intermittent haemodialysis was chosen to expedite clearance of 5-HTP. High-efficiency haemodialysis was initiated, and the dog showed continued clinical improvement throughout the 5-h treatment. Clinical signs resolved completely within 12 h. Sequential blood and urine samples were obtained to document levels of both 5-HTP and serotonin. The dog was discharged 24 h after presentation with complete resolution of clinical signs.
This is the first report documenting the serial changes in 5-HTP concentrations during treatment with haemodialysis.
描述一例犬 5-羟色氨酸(5-HTP)中毒成功接受血液透析治疗的病例。
一只 3 岁、雄性已绝育的拉布拉多猎犬,体重 28.2kg,在摄入含有 200mg 5-HTP 的人类补充剂后约 4-5 小时到急诊就诊。摄入的 5-HTP 量估计在 980 至 1988mg 之间(35-71mg/kg)。就诊时,该犬表现出与血清素综合征一致的进行性神经异常,包括精神状态改变和共济失调。由于摄入剂量大且临床症状进展,选择体外血液净化联合间歇性血液透析以加快 5-HTP 的清除。开始进行高效血液透析,犬在整个 5 小时的治疗过程中持续临床改善。12 小时内临床症状完全缓解。连续采集血液和尿液样本以记录 5-HTP 和血清素的水平。该犬在就诊后 24 小时出院,临床症状完全缓解。
这是首例记录血液透析治疗期间 5-HTP 浓度的连续变化的报告。