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药物和毒素的体外清除

Extracorporeal removal of drugs and toxins.

作者信息

Monaghan Kelly N, Acierno Mark J

机构信息

Department of Small Animal Internal Medicine, Tufts Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA 01536, USA.

出版信息

Vet Clin North Am Small Anim Pract. 2011 Jan;41(1):227-38. doi: 10.1016/j.cvsm.2010.09.005. Epub 2010 Dec 4.

Abstract

Renal replacement therapies (RRT) are increasingly used for the treatment of acute and chronic kidney diseases as well as intoxications and accidental drug overdoses. These therapies offer a mechanism for the removal of toxic substances from the patient's blood and supplement the standard detoxification protocols. If instituted early, RRT can have a significant effect on the course of the toxicity; however, this process is not selective for the removal of only harmful products and can also result in the clearance of medications intended for therapeutic use.

摘要

肾脏替代疗法(RRT)越来越多地用于治疗急慢性肾病以及中毒和意外药物过量。这些疗法提供了一种从患者血液中清除有毒物质的机制,并补充了标准的解毒方案。如果早期实施,RRT可对中毒病程产生显著影响;然而,这个过程并非仅选择性地清除有害产物,也可能导致用于治疗的药物被清除。

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