Department of Drug Science and Technology, University of Turin, via P. Giuria 9, 10125 Turin, Italy.
College of Chemistry and Chemical Engineering of Shantou University, and Chemistry and Chemical Engineering Guangdong Laboratory, 515063 Shantou, PR China.
Food Chem. 2024 Jan 30;432:137168. doi: 10.1016/j.foodchem.2023.137168. Epub 2023 Aug 22.
Herein, an efficient, simple and economical approach to remove antibiotics (ABX), i.e. ceftiofur hydrochloride, sulfamonomethoxine sodium (SMM), marbofloxacin and oxytetracycline by sonication with activated carbon (AC) from cow milk has been successfully implemented. The pseudo-first-order kinetics constants for the sonolytic and sonocatalytic degrading SMM are 0.036 and 0.093 min, respectively. The synergistic efficiency of removing ABX by using sonocatalysis reached 1.8-4.0. Hydrophobic ABX underwent faster degradation than hydrophilic ABX in sonocatalytic systems. Adding 0.5 mmol L HO, the optimal concentration, improved the sonocatalytic degradation rates of ABX by 9.1%-28.5%. Surface area and dose of AC play crucial roles in the sonocatalysis of ABX. By sonicating 50 mL of 5.52 μmol L ABX in milk at 500 kHz and 259 W with 20 mg AC for 20-60 min resulted in residual ABX concentrations ranging from 42.6 to 95.1 μg L, which meet the relative maximum residue limits set by European Commission.
本文成功地提出了一种从牛奶中通过超声与活性炭（AC）联合去除抗生素（ABX），如盐酸头孢噻呋、磺胺甲恶唑钠（SMM）、马波沙星和土霉素的高效、简单且经济的方法。超声降解和超声催化降解 SMM 的伪一级动力学常数分别为 0.036 和 0.093 min。超声催化去除 ABX 的协同效率达到 1.8-4.0。疏水性 ABX 在超声催化体系中比亲水性 ABX 降解得更快。添加 0.5 mmol L HO，最佳浓度可将 ABX 的超声催化降解速率提高 9.1%-28.5%。AC 的表面积和剂量在 ABX 的超声催化中起着关键作用。通过在 500 kHz 和 259 W 下用 20 mg AC 对 50 mL 浓度为 5.52 μmol L 的 ABX 进行 20-60 min 的超声处理，残留 ABX 浓度范围为 42.6-95.1 μg L，符合欧盟委员会设定的相对最大残留限量。
