[Electron-cytochemical study of acetylcholinesterase in the cerebral cortex in Alzheimer's disease].

Electron-cytochemical methods were used to study the distribution of acetylcholinesterase (ACE) activity in the brain in postmortem cases of Alzheimer's disease. The findings showed a decreased number of ACE-positive neural fibers in the upper cortical layers. The reduction was most pronounced in the temporal and parietal lobes of the cortex and absent in the occipital lobe. The disclosed cytochemical changes confirm the presence of disorders in the cholinergic system in the brain cortex in Alzheimer's disease.