Beal M F, Mazurek M F, Svendsen C N, Bird E D, Martin J B
Ann Neurol. 1986 Oct;20(4):489-95. doi: 10.1002/ana.410200408.
Although several studies have documented reduced concentrations of somatostatin-like immunoreactivity (SLI) in the cerebral cortex in Alzheimer's disease, there is controversy concerning the extent and importance of these changes. We measured SLI in brains obtained post mortem from 12 patients with pathologically confirmed Alzheimer's disease and from 13 neurologically normal controls. All major cortical and subcortical regions were examined. Widespread reductions of SLI in Alzheimer's disease cerebral cortex were found, with the most profound changes seen in temporal lobe; but there also were major reductions in both the frontal and occipital cortex. There were no significant reductions in subcortical regions. Characterization of SLI by high-pressure liquid chromatography showed no significant difference in profiles between Alzheimer's disease and control frontal cortex. These results suggest that the reduction in somatostatin immunoreactivity in Alzheimer's disease may be caused by degeneration of intrinsic somatostatin cortical neurons.
尽管多项研究已证明，阿尔茨海默病患者大脑皮质中生长抑素样免疫反应性（SLI）浓度降低，但这些变化的程度和重要性仍存在争议。我们对12例经病理证实为阿尔茨海默病的患者及13名神经功能正常的对照者死后的大脑进行了SLI测定。对所有主要的皮质和皮质下区域进行了检查。结果发现，阿尔茨海默病患者大脑皮质中的SLI普遍降低，其中颞叶变化最为显著；额叶和枕叶皮质也有明显降低。皮质下区域未见明显降低。通过高压液相色谱对SLI进行表征显示，阿尔茨海默病患者与对照者额叶皮质的图谱无显著差异。这些结果表明，阿尔茨海默病中生长抑素免疫反应性降低可能是由皮质内源性生长抑素神经元变性所致。
