Uranova N A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1986;86(7):1016-21.
Following a single or 3-week administration of leponex (clozapine) (in a dose of 10 mg/kg) to rats their brain prefrontal cortices were studied by electron microscopy. Layers III and IV showed hyperchromic pyramidal neurons in different phases of hyperchromia and activation of glial cells. Membranous structures were disclosed in cell somata of individual neurons, dendrites and astrocyte processes. Leponex increased the size of mitochondria and the osmiophilia of their matrix and caused swelling of the cristae in the dendrites near the zone of synaptic contacts. The number of synaptic vesicles, the thickness of the postsynaptic membrane and the size of mitochondria were increased in individual axo-spie and axodendritic synapses. These changes may be secondary to the leponex-induced blockade of postsynaptic receptors.
给大鼠单次或连续3周给予氯氮平（利培酮）（剂量为10毫克/千克）后，通过电子显微镜对其脑前额叶皮质进行了研究。III层和IV层显示出处于不同核染色质增多阶段的深染锥体神经元以及神经胶质细胞的激活。在单个神经元的细胞体、树突和星形胶质细胞突起中发现了膜性结构。利培酮增加了线粒体的大小及其基质的嗜锇性，并导致突触接触区域附近树突中线粒体嵴肿胀。在个别轴-棘突触和轴-树突触中，突触小泡的数量、突触后膜的厚度和线粒体的大小均增加。这些变化可能继发于利培酮诱导的突触后受体阻断。
