Veres A I, Ulashchik V S, Khmara N F, Shuvaev V E
Zh Nevropatol Psikhiatr Im S S Korsakova. 1986;86(7):1057-61.
Glycosaminoglycans (GAGs) and their fractions were measured in relation to age. The material for examination consisted of labile intervertebral disks (27 cases) obtained during operations for discogenic lumbosacral radiculites and disks obtained from people (n = 35) who had died in accidents. The findings showed marked deviations in the total GAGs and their fractions in labile disks, which differed from age-specific changes. The changes revealed in animals with cholesterol atherosclerosis (50 rabbits) and chronic papain degeneration (56 rabbits) resembled those characteristic of vertebral osteochondrosis. It is concluded that degenerative dystrophic changes in osteochondrosis may be induced by both atherosclerotic process and an elevated activity of lysosome enzymes.
对糖胺聚糖（GAGs）及其组分进行了与年龄相关的测定。检测材料包括因椎间盘源性腰骶神经根炎手术中获取的不稳定椎间盘（27例）以及从事故死亡者（n = 35）身上获取的椎间盘。结果显示，不稳定椎间盘中总GAGs及其组分存在明显偏差，这与特定年龄变化不同。在患有胆固醇动脉粥样硬化的动物（50只兔子）和慢性木瓜蛋白酶变性的动物（56只兔子）中所发现的变化类似于脊椎骨软骨病的特征变化。得出的结论是，骨软骨病中的退行性营养不良性变化可能由动脉粥样硬化过程和溶酶体酶活性升高共同诱发。
