Kitano T, Zerwekh J E, Usui Y, Edwards M L, Flicker P L, Mooney V
Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas 75235-8885.
Clin Orthop Relat Res. 1993 Aug(293):372-7.
Significant changes in disk biochemistry were evident in the nuclei pulposi of 25 symptomatic disks that demonstrated abnormal diskography. Compared with the results from ten normal disk from young subjects (mean age, ten years) and from ten asymptomatic disks from adult patients (mean age, 33 years), the symptomatic disks demonstrated significantly greater collagen content than the young and asymptomatic adult subjects, respectively. Significantly fewer total glycosaminoglycans (GAGs) and significantly less water content were also evident for the diseased disks. The mean pH of the nucleus pulposus from 23 patients was also significantly reduced for the symptomatic disks as compared with the mean pH measured for four asymptomatic adult subjects. Although significantly fewer total GAGs were observed for the symptomatic disks, there were no significant differences in the percent composition of hyaluronic acid (HA), chondroitin sulfate (CS), or keratan sulfate (KS) among the normal and symptomatic disks. Significant changes in disk biochemistry are associated with the symptomatic disk, and these changes could contribute to the development of the painful disk syndrome.
在25个显示椎间盘造影异常的有症状椎间盘的髓核中，椎间盘生物化学发生了显著变化。与10个来自年轻受试者（平均年龄10岁）的正常椎间盘以及10个来自成年患者（平均年龄33岁）的无症状椎间盘的结果相比，有症状的椎间盘显示出的胶原蛋白含量分别显著高于年轻受试者和无症状成年受试者。患病椎间盘的总糖胺聚糖（GAGs）明显减少，含水量也显著降低。与4名无症状成年受试者测得的平均pH值相比，23名患者有症状椎间盘的髓核平均pH值也显著降低。尽管有症状椎间盘的总GAGs明显较少，但正常椎间盘和有症状椎间盘之间透明质酸（HA）、硫酸软骨素（CS）或硫酸角质素（KS）的百分比组成没有显著差异。椎间盘生物化学的显著变化与有症状的椎间盘有关，这些变化可能导致疼痛性椎间盘综合征的发生。
