Nogaret J M, André J, Parent D, Verhest A, Lejeune F J, Achten G
Acta Chir Belg. 1986 Jul-Aug;86(4):238-44.
Twenty cases of melanomas of the extremities observed in Brussels, Belgium, between 1968 and 1981 were reviewed. The clinical and histological characteristics, the treatment and the evolution were analyzed and compared to the data of the literature. Diagnosis was often delayed, as it was rendered difficult by the misleading clinical symptoms. This delay explains the inadequacy of numerous treatments given prior to the definitive one as well as the high thickness of the melanomas at the time of diagnosis. The five year survival was only 50%. An early diagnosis made by excisional biopsy, if possible, and an adequate treatment given to start with, should improve the result.
回顾了1968年至1981年间在比利时布鲁塞尔观察到的20例四肢黑色素瘤病例。分析了其临床和组织学特征、治疗方法及病情演变，并与文献数据进行了比较。由于临床症状具有误导性，诊断常常延迟。这种延迟解释了在最终诊断之前进行的许多治疗为何不充分，以及诊断时黑色素瘤的厚度为何较高。五年生存率仅为50%。若可能，通过切除活检进行早期诊断，并从一开始就给予充分治疗，应能改善治疗效果。
