Wennlund A
Acta Endocrinol (Copenh). 1986 Sep;113(1):47-9. doi: 10.1530/acta.0.1130047.
Serum levels of T3, T4, FT4 and TSH were determined in 9 euthyroid patients during 6 h after intake of morning thyroxine replacement medication. Four hypothyroid patients were studied in the same way after the intake of 50 micrograms thyroxine. In the euthyroid patients the FT4 level increased by 31%, while the increase of T4 was 16% and the increase of T3 11%. In the hypothyroid patients levels of T3, T4 and FT4 did not change after ingestion of 50 micrograms thyroxine, while the TSH level was decreased by 30%. It is concluded that during thyroxine replacement therapy hormone analysis must be interpreted in relation to the time of thyroxine administration.
在9名甲状腺功能正常的患者服用早晨甲状腺素替代药物后的6小时内，测定其血清T3、T4、游离T4（FT4）和促甲状腺激素（TSH）水平。4名甲状腺功能减退患者在服用50微克甲状腺素后，以同样的方式进行研究。在甲状腺功能正常的患者中，FT4水平升高了31%，而T4升高了16%，T3升高了11%。在甲状腺功能减退的患者中，服用50微克甲状腺素后，T3、T4和FT4水平没有变化，而TSH水平下降了30%。得出的结论是，在甲状腺素替代治疗期间，必须结合甲状腺素给药时间来解释激素分析结果。
