Inada M, Nishikawa M, Naito K, Ishii H, Tanaka K, Kurata S, Oishi M, Imura H
Endocrinol Jpn. 1980 Jun;27(3):291-5. doi: 10.1507/endocrj1954.27.291.
In order to investigate the effect of 3,5,3'L-triiodothyronine (T3) administration on thyroid hormone concentrations in serum, thyroxine (T4), T3, 3,3',5'L-triiodothyronine (reverse T3, rT3) and thyroid stimulating hormone (TSH) concentrations in serum were determined before and after T3 administration in 10 hypothyroid patients maintained on constant doses of T4. Ten hypothyroid patients given 100 micrograms of T4 for approximately 3 months had almost normal T4 and T3 concentrations in serum. Seven patients showed almost normal rT3 concentrations in serum and they were slightly diminished in the remaining 3 patients. TSH levels in serum were almost within the normal limit in 7 out of 10 patients. However, despite the elevation of T4 and T3 levels, 3 patients had markedly elevated TSH levels. Values for serum T4 concentrations were decreased 4 weeks after the administration of 50 micrograms T3 in all patients maintained on constant doses of T4, although they were almost within the normal range. T3 concentrations in serum, which was obtained just before the administration of the next daily doses of T3, were markedly elevated in 6 of 10 patients after T3 administration and the remaining 4 patients had also slightly higher T3 concentrations than those before T3 administration. On the other hand, serum rT3 concentrations were diminished in 5 patients during T3 ingestion. They were somewhat diminished or almost unchanged before and after T3 administration in the remai T3 administration and the remaining 4 patients had also slightly higher T3 concentrations than those before T3 administration. On the other hand, serum rT3 concentrations were diminished in 5 patients during T3 ingestion. They were somewhat diminished or almost unchanged before and after T3 administration in the remaining 5 patients. Moreover, 3 patients with elevated TSH levels during T4 administration showed almost normal TSH levels after T4 and T3 ingestion. The results showed the reciprocal relationship between T3 and rT3 levels in serum after T3 administration in hypothyroid patients maintained on constant doses of T4. Furthermore, the present findings suggest that the administration of both T4 and T3 might be a more suitable replacement therapy in the patients with hypothyroidism than T4 alone.
为了研究给予3,5,3'-三碘甲腺原氨酸（T3）对血清中甲状腺激素浓度的影响，我们测定了10例持续服用恒定剂量甲状腺素（T4）的甲状腺功能减退患者在给予T3前后血清中的甲状腺素（T4）、T3、3,3',5'-三碘甲腺原氨酸（反式T3，rT3）和促甲状腺激素（TSH）浓度。10例给予100微克T4约3个月的甲状腺功能减退患者血清中的T4和T3浓度几乎正常。7例患者血清中的rT3浓度几乎正常，其余3例患者的rT3浓度略有降低。10例患者中有7例血清中的TSH水平几乎在正常范围内。然而，尽管T4和T3水平升高，但仍有3例患者的TSH水平显著升高。在持续服用恒定剂量T4的所有患者中，给予50微克T3 4周后血清T4浓度值下降，尽管其几乎在正常范围内。在给予下一次每日剂量T3之前所测得的血清T3浓度，在给予T3后10例患者中有6例显著升高，其余4例患者的T3浓度也略高于给予T3之前。另一方面，5例患者在服用T3期间血清rT3浓度降低。其余5例患者在给予T3前后rT3浓度略有降低或几乎未变。此外，3例在服用T4期间TSH水平升高的患者在服用T4和T3后TSH水平几乎正常。结果显示，在持续服用恒定剂量T4的甲状腺功能减退患者中，给予T3后血清中T3和rT3水平呈相互关系。此外，目前的研究结果表明，对于甲状腺功能减退患者来说，同时给予T4和T3可能比单独给予T4是更合适的替代疗法。
