Edelris, Bioparc, Bioserra 1 Building, Lyon, France.
High Throughput Screening, Hit Discovery, Discovery Sciences, R&D Biopharmaceuticals, AstraZeneca, Alderley Park, UK.
Drug Discov Today. 2023 Nov;28(11):103760. doi: 10.1016/j.drudis.2023.103760. Epub 2023 Sep 1.
Affinity selection mass spectrometry (AS-MS) has gained momentum in drug discovery. This review summarizes how this technology has slowly risen as a new paradigm in hit identification and its potential synergy with DNA encoded library technology. It presents an overview of the recent results on challenging targets and perspectives on new areas of research, such as RNA targeting with small molecules. The versatility of the approach is illustrated and strategic drivers discussed in terms of the experience of a small-medium CRO and a big pharma organization.
亲和选择质谱 (AS-MS) 在药物发现领域中得到了广泛应用。本综述总结了该技术如何逐渐成为一种新的发现方法，并与 DNA 编码文库技术产生协同作用。本文介绍了在具有挑战性的靶点方面的最新研究成果，并探讨了小分子靶向 RNA 等新的研究领域的前景。本文还阐述了该方法的多功能性，并从小型中型 CRO 和大型制药公司的经验出发，讨论了战略驱动因素。
