Alum Esther Ugo, Udechukwu Chidozie Dennis, Obasi David Chukwu
Department of Research and Publications, Kampala International University, P. O. Box 20000, Kampala, Uganda.
Department of Biology, Faculty of Biological Sciences, Alex Ekwueme Federal University Ndufu Alike, Abakaliki, Abakaliki Ebonyi State, Nigeria.
Mol Biol Rep. 2025 Jun 4;52(1):549. doi: 10.1007/s11033-025-10650-9.
Precision medicine aims to revolutionize healthcare by tailoring treatments to the unique genetic, molecular, and environmental profiles of individuals. Among the innovative approaches in this field, allosteric modulation has emerged as a powerful strategy for therapeutic intervention. Allosteric modulators regulate protein activity by binding to sites distinct from the active site, offering enhanced specificity, versatility, and control over biological processes. This review explores the integration of allosteric modulation with precision medicine, highlighting its potential to address unmet medical needs in complex diseases such as cancer, neurodegenerative disorders, and metabolic conditions. The study utilized databases like PubMed, Scopus, and Web of Science to conduct a thorough search of peer-reviewed articles, reviews, and case studies published between 2012 and 2024. Allosteric modulators, driven by advancements in structural biology, artificial intelligence, and high-throughput screening, offer unique advantages in targeting undruggable proteins and overcoming drug resistance in personalized treatment strategies. The article discusses challenges in allosteric drug development, including off-target effects and clinical translation, and provides a framework for overcoming these barriers. This review highlights allosteric modulation's potential to revolutionise therapeutic strategies by enabling highly targeted, effective, and individualised treatments in next-generation healthcare.
精准医学旨在通过根据个体独特的基因、分子和环境特征量身定制治疗方案，来彻底改变医疗保健模式。在该领域的创新方法中，变构调节已成为一种强大的治疗干预策略。变构调节剂通过结合与活性位点不同的位点来调节蛋白质活性，在增强特异性、通用性以及对生物过程的控制方面具有优势。本综述探讨了变构调节与精准医学的整合，强调了其在满足癌症、神经退行性疾病和代谢性疾病等复杂疾病中未满足的医疗需求方面的潜力。该研究利用了PubMed、Scopus和Web of Science等数据库，对2012年至2024年期间发表的同行评审文章、综述和案例研究进行了全面搜索。受结构生物学、人工智能和高通量筛选进展推动的变构调节剂，在靶向难以成药的蛋白质和克服个性化治疗策略中的耐药性方面具有独特优势。本文讨论了变构药物开发中的挑战，包括脱靶效应和临床转化，并提供了克服这些障碍的框架。本综述强调了变构调节在下一代医疗保健中实现高度靶向、有效和个性化治疗，从而彻底改变治疗策略的潜力。
