Department of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan.
Department of Endoscopy, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Am J Med Sci. 2023 Dec;366(6):421-429. doi: 10.1016/j.amjms.2023.08.012. Epub 2023 Sep 1.
Non-Helicobacter pylori Helicobacter (NHPH) has recently been linked to various gastric diseases. However, the relationship between NHPH infection and gastric cancer remains controversial. This study aimed to identify the effect of NHPH infection on gastritis and gastric cancer development.
Formalin-fixed paraffin-embedded tissues were obtained from 73 patients with gastric cancer, of whom 21 cases were Helicobacter pylori (Hp) current infection, 37 cases were Hp previous infection, and 15 cases were Hp naïve infection, and were screened for NPHPs using polymerase chain reaction. The results were compared with NHPH infection rates in the patients with gastritis-related diseases reported in the previous study. We evaluated the association of NHPH infection with gastritis and clinicopathological features of gastric cancer.
NHPH infection rates were 4/21 (19%) in "Hp current" patients, 4/37 (11%) in "Hp previous" infection patients, and 1/15 (7%) in "Hp naïve" patients, showing no significant difference in infection rates based on Hp infection status. NHPH infection rates in gastric cancer patients were similar to those in the patients with gastritis-related diseases reported in the previous study. A comparison of NHPH-positive and negative patients showed no significant differences in atrophic gastritis status, serum gastritis markers, or clinicopathological characteristics of gastric cancer, such as localization, size, gross type, differentiation, or depth.
The association between gastric cancer and NHPH infection would have important implications for gastric cancer prevention, diagnostics, and treatment, however, no significant association was found in this particular population.
非幽门螺杆菌 Helicobacter（NHPH）最近与各种胃部疾病有关。然而，NHPH 感染与胃癌之间的关系仍存在争议。本研究旨在确定 NHPH 感染对胃炎和胃癌发展的影响。
从 73 例胃癌患者中获得福尔马林固定石蜡包埋组织，其中 21 例为幽门螺杆菌（Hp）现症感染，37 例为 Hp 既往感染，15 例为 Hp 未感染，并使用聚合酶链反应筛查 NHPH。结果与既往研究中报道的与胃炎相关疾病患者的 NHPH 感染率进行比较。我们评估了 NHPH 感染与胃炎和胃癌临床病理特征的关系。
“Hp 现症”患者中 NHPH 感染率为 4/21（19%），“Hp 既往”感染患者中为 4/37（11%），“Hp 未感染”患者中为 1/15（7%），感染率与 Hp 感染状态无显著差异。胃癌患者的 NHPH 感染率与既往研究中报道的与胃炎相关疾病患者的感染率相似。NHPH 阳性和阴性患者之间的比较显示，萎缩性胃炎状态、血清胃炎标志物或胃癌的临床病理特征（如定位、大小、大体类型、分化或深度）无显著差异。
胃癌与 NHPH 感染之间的关联对胃癌的预防、诊断和治疗具有重要意义，然而，在这一特定人群中未发现显著关联。
