Yamada G, Manabe K, Nagashima H
Acta Med Okayama. 1986 Aug;40(4):225-8. doi: 10.18926/AMO/31906.
Liver biopsy specimens obtained from a 31-year-old female with delta-positive hepatitis were studied by routine electron microscopy. In several nuclei of hepatocytes, there were filamentous or microtubular structures 15 to 20 nm in diameter, in the vicinity of which, round particles, probably cross sections of tubular ones, were seen. In these nuclei, irregular granules approximately 20 to 30 nm in diameter were also found in clusters. However, cores of Dane particles were not found in such hepatocytes. These intranuclear microtubular structures may be associated with delta agent.
对一名患有δ阳性肝炎的31岁女性的肝活检标本进行了常规电子显微镜研究。在肝细胞的几个细胞核中，有直径为15至20纳米的丝状或微管状结构，在其附近可见圆形颗粒，可能是管状颗粒的横截面。在这些细胞核中，还发现直径约20至30纳米的不规则颗粒成簇存在。然而，在这类肝细胞中未发现丹氏颗粒的核心。这些核内微管状结构可能与δ因子有关。
