Ericsson U B, Thorell J I
Acta Med Scand. 1986;220(1):47-56. doi: 10.1111/j.0954-6820.1986.tb02729.x.
A number of 2 325 serum samples from a population of in- and outpatients were collected during a six-month period in order to evaluate the usefulness of various thyroid function tests in the clinical laboratory routine. The samples were analysed with the following thyroid function tests: total triiodothyronine (T3) (TT3), total thyroxine (T4) (TT4), free T3 index (FT3I), free T4 index (FT4I) and thyrotropin (TSH). One to two years after the primary evaluation, a follow-up was performed and the final diagnoses were checked in the patients' records. The values of these parameters in the diagnosis of hyperthyroidism were: FT3I greater than FT4I greater than TT3 greater than TT4. The corresponding results in the diagnosis of hypothyroidism were: TSH greater than FT4I greater than FT3I = TT3. No single test could detect both hyper- and hypothyroidism effectively. The only one-step strategy for thyroid evaluation in patients without apparent clinical signs of hyper- or hypothyroidism would therefore be the combined determination of T3 and TSH. The study also showed distinct differences between the reference values of the healthy population and patients without thyroid disorders.
在六个月的时间里，收集了一组门诊和住院患者的2325份血清样本，以评估各种甲状腺功能测试在临床实验室常规检测中的实用性。对这些样本进行了以下甲状腺功能测试分析：总三碘甲状腺原氨酸（T3）（TT3）、总甲状腺素（T4）（TT4）、游离T3指数（FT3I）、游离T4指数（FT4I）和促甲状腺激素（TSH）。在初次评估后的一到两年进行了随访，并在患者记录中检查最终诊断结果。这些参数在甲状腺功能亢进诊断中的数值为：FT3I＞FT4I＞TT3＞TT4。甲状腺功能减退诊断中的相应结果为：TSH＞FT4I＞FT3I = TT3。没有单一测试能够有效检测甲状腺功能亢进和减退。因此，对于没有明显甲状腺功能亢进或减退临床体征的患者，唯一的一步式甲状腺评估策略是联合测定T3和TSH。该研究还显示了健康人群和无甲状腺疾病患者参考值之间的明显差异。
