Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, United States.
Chemical and Biological Engineering Department, Drexel University, Philadelphia, PA, United States.
Front Immunol. 2023 Aug 16;14:1221008. doi: 10.3389/fimmu.2023.1221008. eCollection 2023.
Recent advancements in immunology and chemistry have facilitated advancements in targeted vaccine technology. Targeting specific cell types, tissue locations, or receptors can allow for modulation of the adaptive immune response to vaccines. This review provides an overview of cellular targets of vaccines, suggests methods of targeting and downstream effects on immune responses, and summarizes general trends in the literature. Understanding the relationships between vaccine targets and subsequent adaptive immune responses is critical for effective vaccine design. This knowledge could facilitate design of more effective, disease-specialized vaccines.
近年来免疫学和化学领域的进展促进了靶向疫苗技术的发展。针对特定的细胞类型、组织位置或受体进行靶向，可以调节疫苗引起的适应性免疫反应。本文综述了疫苗的细胞靶点，提出了靶向方法和对免疫反应的下游影响，并总结了文献中的一般趋势。了解疫苗靶点与随后的适应性免疫反应之间的关系对于有效的疫苗设计至关重要。这些知识可以促进更有效、针对特定疾病的疫苗的设计。
