体内抗雌激素预处理对家兔心房对组胺的变时反应的影响。

Effect of in vivo antiestrogen pretreatment on rabbit atrial chronotropic response to histamine.

作者信息

Baksi S N, Hughes M J

出版信息

Agents Actions. 1986 Aug;18(5-6):463-7. doi: 10.1007/BF01964947.

DOI:10.1007/BF01964947

Abstract

The chronotropic response (delta rate) to histamine (1.4 to 18 X 10(-6) M) of isolated atria from antiestrogen (tamoxifen)-pretreated immature female rabbit was investigated. Tamoxifen treatment (1.0 and 10.0 mg/kg/day for 14 days) had no significant effect on the delta rate. The Rmax and D1/2max were not significantly different in the two tamoxifen-treated groups compared to the oil-treated (1.0 ml/kg/day for 14 days) control group. Cimetidine (2.8 X 10(-7) M) inhibited the delta rate to histamine in all groups: control, 27%; tamoxifen (1.0 mg/kg), 38%; and tamoxifen (10.0 mg/kg), 28%. Only the low dose of tamoxifen was found to be estrogenic (uterotropic). We conclude that tamoxifen pretreatment, both at estrogen-agonist and estrogen-antagonist doses, is without effect on atrial chronotropic response to histamine.

摘要

研究了抗雌激素（他莫昔芬）预处理的未成熟雌性兔离体心房对组胺（1.4至18×10⁻⁶ M）的变时反应（心率变化率）。他莫昔芬处理（1.0和10.0 mg/kg/天，共14天）对心率变化率无显著影响。与油处理（1.0 ml/kg/天，共14天）对照组相比，两个他莫昔芬处理组的Rmax和D1/2max无显著差异。西咪替丁（2.8×10⁻⁷ M）抑制了所有组对组胺的心率变化率：对照组为27%；他莫昔芬（1.0 mg/kg）组为38%；他莫昔芬（10.0 mg/kg）组为28%。仅发现低剂量的他莫昔芬具有雌激素样作用（促子宫生长）。我们得出结论，无论是雌激素激动剂剂量还是雌激素拮抗剂剂量的他莫昔芬预处理，对心房对组胺的变时反应均无影响。