雌二醇对兔心房组胺变时反应的调节作用。
Modulation by estradiol of rabbit atrial chronotropic response to histamine.
作者信息
Baksi S N, Hughes M J
出版信息
Basic Res Cardiol. 1983 Sep-Oct;78(5):505-9. doi: 10.1007/BF01906461.
The chronotropic response (delta rate) to histamine of atria from estradiol 17-beta (E2; 0.1 mg/kg)-treated (14 days) rabbit was significantly greater compared to those from control rabbits. However, the maximum response of atria from rabbits treated with a higher dose of E2 (1.0 mg/kg) was not significantly different from control. Cimetidine (2.8 X 10(-7) M) inhibited the theoretical maximum income in rate to histamine in all 3 groups, control 25%, E2 (0.1 mg) 42% and E2 (1.0 mg) 35%.
与对照兔相比，用17-β雌二醇（E2；0.1mg/kg）处理（14天）的兔心房对组胺的变时反应（心率变化率）显著更大。然而，用更高剂量E2（1.0mg/kg）处理的兔心房的最大反应与对照无显著差异。西咪替丁（2.8×10⁻⁷M）抑制了所有3组对组胺的理论最大心率增加，对照组为25%，E2（0.1mg）组为42%，E2（1.0mg）组为35%。
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