Reddy Kallem Venkat, Lakshmi Challa V S, Kiran Sai, Murki Srinivas
DNB Resident, Fernandez Hospital Hyderguda, Hyderabad, India.
Cradle Hospital, Hyderabad, India.
Sudan J Paediatr. 2023;23(1):68-73. doi: 10.24911/SJP.106-1560160872.
Very low birth weight (VLBW) infants comprise between 4% and 8% of live-births and about one-third of deaths during the neonatal period. The objective of the study is to evaluate and compare the long-term growth outcomes of VLBW infants among two different birth cohorts: Cohort 2007-08 (cohort 1) and cohort 2015-16 (cohort 2), in a cross-sectional observational study. The neonatal and perinatal data of cohort 1 was collected from available trial data and the same data from cohort 2 was collected from patient case files and patient history. The primary outcome of the study was to compare the growth outcomes of VLBW infants attending the follow-up clinic between 12 and 18 months of corrected age from two different birth cohorts. Respectively, 238 and 268 infants were eligible for inclusion in cohort 1 and 2. Among the eligible infants, 148 infants in cohort 1 and 178 infants in cohort 2 were available for primary outcome assessment during the recruitment phase. The weight and length at corrected age (12 to 18 months) is significantly higher in cohort 2 compared to that in cohorts 1 although the mean age at assessment is similar between the two groups. There is a significant reduction in the incidence of underweight in infants that belonged to cohort 2. The proportions of infants who are underweight at follow-up were significantly lower in cohort 2 when compared to cohort 1, and there were no significant differences in the incidence of stunting and microcephaly among both the cohorts.
极低出生体重（VLBW）婴儿占活产婴儿的4%至8%，约占新生儿期死亡人数的三分之一。本研究的目的是在一项横断面观察性研究中，评估和比较两个不同出生队列（2007 - 08队列，即队列1；以及2015 - 16队列，即队列2）中VLBW婴儿的长期生长结局。队列1的新生儿和围产期数据从现有试验数据中收集，队列2的相同数据从患者病例档案和患者病史中收集。本研究的主要结局是比较来自两个不同出生队列、矫正年龄在12至18个月之间且到随访门诊就诊的VLBW婴儿的生长结局。队列1和队列2分别有238名和268名婴儿符合纳入条件。在符合条件的婴儿中，队列1有148名婴儿、队列2有178名婴儿在招募阶段可用于主要结局评估。尽管两组的平均评估年龄相似，但队列2中矫正年龄（12至18个月）时的体重和身长显著高于队列1。队列2中婴儿体重不足的发生率显著降低。与队列1相比，队列2中随访时体重不足的婴儿比例显著更低，并且两个队列中发育迟缓与小头畸形的发生率没有显著差异。
