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埃塞俄比亚东部哈勒尔市希沃特·法纳专科医院重度急性营养不良儿童的治疗结果及相关因素:一项回顾性队列研究

Treatment outcomes and associated factors among children with severe acute malnutrition at Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia: a retrospective cohort study.

作者信息

Aye Addis, Amare Frehiwot, Sosengo Teshome

机构信息

School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Dire Dawa, Ethiopia.

School of Pharmacy, Department of Clinical Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia.

出版信息

Sudan J Paediatr. 2023;23(1):32-41. doi: 10.24911/SJP.106-1635757512.

Abstract

Ethiopia is one of the countries with the highest under-five child mortality rates, with malnutrition remaining the major cause of death. Overall, 10% of children in Ethiopia are wasted, and 3% are severely wasted. To assess the treatment outcomes and associated factors among children with severe acute malnutrition (SAM) at Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia, data of 162 under-five children admitted from January to December, 2020, at Hiwot Fana Specialized University hospital were collected retrospectively from 1 January to 20 February 2021. Pre-tested structured questionnaire was used to extract data from medical records. The data was entered into Statistical Package for the Social Sciences version 21 for analysis. A -value <0.05 was considered statistically significant. In this study, 162 participants were included and 54% were males. The majority (80.2%) of children were newly admitted and 49.7% had less than 7 days of hospital stay, 70.99% recovered from malnutrition, and 42.6% had marasmus. Amoxicillin and gentamycin combination (47.5%) was the most commonly prescribed intravenous antibiotics. Having diarrhoea (AOR = 22, 95% CI: 2.86-169.46), presence of comorbidities such as malaria (AOR = 103.29, 95% CI: 7.42-1437.74) and human immunodeficiency virus (HIV) (AOR = 42.72, 95% CI: 4.47-408.23) were statistically associated with poor recovery from severe malnutrition. More than 70% of children with SAM had good treatment outcomes. Child vaccination history, length of hospital stay, admission weight for height, and presence of comorbidities such as diarrhoea, pneumonia, measles, HIV, malaria, and tuberculosis were factors associated with bad malnutrition and treatment outcomes.

摘要

埃塞俄比亚是五岁以下儿童死亡率最高的国家之一,营养不良仍然是主要死因。总体而言,埃塞俄比亚10%的儿童消瘦,3%的儿童严重消瘦。为了评估埃塞俄比亚东部哈勒尔市希沃特·法纳专科医院中重度急性营养不良(SAM)儿童的治疗效果及相关因素,我们于2021年1月1日至2月20日回顾性收集了希沃特·法纳专科医院2020年1月至12月收治的162名五岁以下儿童的数据。采用预先测试的结构化问卷从病历中提取数据。数据录入社会科学统计软件包第21版进行分析。P值<0.05被认为具有统计学意义。本研究纳入了162名参与者,其中54%为男性。大多数儿童(80.2%)是新入院的,49.7%的儿童住院时间少于7天,70.99%的儿童营养不良得到康复,42.6%的儿童患有消瘦症。阿莫西林和庆大霉素联合用药(47.5%)是最常用的静脉注射抗生素。患有腹泻(比值比=22,95%置信区间:2.86 - 169.46)、存在疟疾(比值比=103.29,95%置信区间:7.42 - 1437.74)和人类免疫缺陷病毒(HIV)(比值比=42.72,95%置信区间:4.47 - 408.23)等合并症与重度营养不良康复不佳在统计学上相关。超过70%的重度急性营养不良儿童治疗效果良好。儿童疫苗接种史、住院时间、入院时身高体重以及腹泻、肺炎、麻疹、HIV、疟疾和结核病等合并症的存在是与严重营养不良和治疗效果相关的因素。

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