Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, People's Republic of China.
Anhui Province Key Laboratory of Brain Function and Brain Disease, Hefei, People's Republic of China.
Clin Interv Aging. 2023 Aug 29;18:1437-1445. doi: 10.2147/CIA.S422605. eCollection 2023.
Anxiety is one of the most common and disturbing non-motor symptoms of Parkinson's disease (PD). However, few studies have explored the relationship between functional connectivity (FC) and the rate of anxiety improvement after subthalamic nucleus deep brain stimulation (STN-DBS). Therefore, in this study, we aimed to explore the correlation between FC and the rate of anxiety improvement in patients with PD who underwent STN-DBS.
The resting-state functional magnetic resonance imaging (rs-fMRI) data of 62 patients with anxious PD (aPD), 68 patients with PD without anxiety (naPD), and 64 healthy controls (HCs) were analyzed according to FC. Intergroup comparison and correlation analyses of anxiety improvement rates were performed.
The HC, aPD and naPD groups of zFCs were then used for the ANOVA test, and the results were FDR-corrected. There were 24 significant differences in FCs between the three groups. Post tests were conducted between groups found that 15 significantly different FCs were observed between the naPD and aPD groups. In addition, the two FCs in patients with aPD were significantly correlated with the rate of improvement in anxiety.
We found that the two FCs in patients with aPD (olfactory cortex and inferior frontal gyrus [IFG] pars orbitalis; inferior temporal gyrus and posterior orbital gyrus) were significantly correlated with the rate of improvement in anxiety. Our study may help us understand the underlying mechanisms by which STN-DBS improves anxiety in PD patients and identify more effective treatment strategies.
焦虑是帕金森病（PD）最常见和最令人不安的非运动症状之一。然而，很少有研究探讨功能连接（FC）与丘脑底核深部脑刺激（STN-DBS）后焦虑改善率之间的关系。因此，在这项研究中，我们旨在探讨接受 STN-DBS 的 PD 患者 FC 与焦虑改善率之间的相关性。
根据 FC 分析了 62 例有焦虑 PD（aPD）、68 例无焦虑 PD（naPD）和 64 例健康对照（HC）的静息态功能磁共振成像（rs-fMRI）数据。进行了组间比较和焦虑改善率的相关性分析。
然后对 HC、aPD 和 naPD 组的 zFC 进行 ANOVA 检验，并进行 FDR 校正。三组间存在 24 个 FC 的显著差异。组间后测试发现，naPD 和 aPD 组之间存在 15 个明显不同的 FC。此外，aPD 患者的两个 FC 与焦虑改善率显著相关。
我们发现，aPD 患者的两个 FC（嗅觉皮层和眶额下回；颞下回和眶后回）与焦虑改善率显著相关。我们的研究可能有助于我们了解 STN-DBS 改善 PD 患者焦虑的潜在机制，并确定更有效的治疗策略。
