Mei Jiaming, Chang Bowen, Xiong Chi, Jiang Manli, Niu Chaoshi
Department of Neurosurgery, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.
Front Neurol. 2022 Jun 10;13:916658. doi: 10.3389/fneur.2022.916658. eCollection 2022.
Programming plays an important role in the outcome of deep brain stimulation (DBS) for Parkinson's disease (PD). This study introduced a new application for functional zonal image reconstruction in programming.
Follow-up outcomes were retrospectively compared, including first programming time, number of discomfort episodes during programming, and total number of programming sessions between patients who underwent image-reconstruction-guided programming and those who underwent conventional programming. Data from 142 PD patients who underwent subthalamic nucleus (STN)-DBS between January 2017 and June 2019 were retrospectively analyzed. There were 75 conventional programs and 67 image reconstruction-guided programs.
At 1-year follow-up, there was no significant difference in the rate of stimulus improvement or superposition improvement between the two groups. However, patients who underwent image reconstruction-guided programming were significantly better at the first programming time, number of discomfort episodes during programming, and total number of programming sessions than those who underwent conventional programming.
Imaging-guided programming of directional DBS leads was possible and led to reduced programming time and reduced patient side effects compared with conventional programming.
程控在帕金森病（PD）的脑深部电刺激（DBS）治疗结果中起着重要作用。本研究介绍了一种在程控中进行功能分区图像重建的新应用。
回顾性比较随访结果，包括首次程控时间、程控期间不适发作次数以及接受图像重建引导程控的患者与接受传统程控的患者之间的程控总次数。对2017年1月至2019年6月期间接受丘脑底核（STN）-DBS治疗的142例PD患者的数据进行回顾性分析。其中有75例传统程控和67例图像重建引导程控。
在1年的随访中，两组之间的刺激改善率或叠加改善率没有显著差异。然而，接受图像重建引导程控的患者在首次程控时间、程控期间不适发作次数以及程控总次数方面明显优于接受传统程控的患者。
与传统程控相比，定向DBS电极的影像引导程控是可行的，且可减少程控时间和患者的副作用。
