Soares Cláudio Beling Gonçalves, Araújo Ivana Duval de, Teixeira Luiz Eduardo Moreira, Michelin Márcia Antoniazi, Machado Carla Jorge, Silveira Marcelo Peixoto
Médico Preceptor, Departamento de Cirurgia, Faculdade de Medicina Federal, Universidade de Minas Gerais, Belo Horizonte, MG, Brasil.
Professor, Departamento de Cirurgia, Faculdade de Medicina, Universidade Federal, Minas Gerais, Belo Horizonte, MG, Brasil.
Rev Bras Ortop (Sao Paulo). 2023 Jul 4;58(4):e653-e658. doi: 10.1055/s-0042-1758359. eCollection 2023 Aug.
We aim to describe an experimental model for studying femoral fractures in rats after exposure to ionizing radiation, demonstrating a way to apply a substance for analysis, the method for patterning fracture and irradiation, and how to evaluate its effectiveness based on radiographic studies. We used 24 rats divided into 2 groups of 12 animals each. The STUDY group was exposed to ionizing radiation and treated with saline solution, and the CONTROL group was not exposed to radiation and was treated with saline solution. All animals were subjected to standardized fracture of the right femur that was fixed with intramedullary wire. The efficiency of the bone union was assessed by radiographic exam. Fracture healing was more efficient in bones not exposed to ionizing radiation ( = 0.012). All fractures met the criteria of being simple, diaphyseal, transverse or short oblique. The experimental model presented is an efficient alternative for the study of fractures in irradiated bones in rats.
我们旨在描述一种用于研究大鼠在暴露于电离辐射后股骨骨折的实验模型，展示一种应用物质进行分析的方法、骨折和辐射的模式化方法，以及如何基于放射学研究评估其有效性。我们使用了24只大鼠，分为2组，每组12只动物。研究组暴露于电离辐射并用盐溶液治疗，对照组未暴露于辐射并用盐溶液治疗。所有动物均接受右股骨标准化骨折，并用髓内钢丝固定。通过放射学检查评估骨愈合效率。未暴露于电离辐射的骨骼骨折愈合更有效（ = 0.012）。所有骨折均符合简单、骨干、横行或短斜行的标准。所呈现的实验模型是研究大鼠受辐照骨骼骨折的有效替代方法。
