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对包括急性髓系白血病在内的多种癌症中具有潜在预后和免疫治疗价值的基因进行泛癌分析。

Pan-cancer analysis of the gene with potential prognostic and immunotherapeutic values in multiple cancers including acute myeloid leukemia.

作者信息

Li Qi, Cheng Yujing, Chen Wanlu, Wang Ying, Dai Run, Yang Xin

机构信息

Department of Blood Transfusion, The First People's Hospital of Yunnan Province - The Affiliated Hospital of Kunming University of Science and Technology, 650032 Kunming, Yunnan, China.

出版信息

Open Med (Wars). 2023 Aug 28;18(1):20230782. doi: 10.1515/med-2023-0782. eCollection 2023.

DOI:10.1515/med-2023-0782
PMID:37663233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10473463/
Abstract

Phosphodiesterase 4D interacting protein () interacts with cAMP-specific phosphodiesterase 4D and its abnormal expression promotes the development of hematological malignancies, breast cancer, and pineal cell carcinoma. However, there is currently no systematic pan-cancer analysis of the association between and various cancers. Thus, this study aimed to elucidate the potential functions of in various cancers. Based on the multiple public databases and online websites, we conducted comprehensive analyses for in various cancers, including differential expression, prognosis, genetic variation, DNA methylation, and immunity. We thoroughly analyzed the specific role of in acute myeloid leukemia (LAML). The results indicated that there were differences in expression in cancers, and in kidney chromophobe, LAML, pheochromocytoma and paraganglioma, thymoma, and uveal melanoma, had potential prognostic value. expression was also correlated with genetic variation, DNA methylation, immune cell infiltration, and immune-related genes in cancers. Functional enrichment analysis showed that was mainly related to immune-related pathways in cancers, and in LAML, was mainly related to immunoglobulin complexes, T-cell receptor complexes, and immune response regulatory signaling pathways. Our study systematically revealed for the first time the potential prognostic and immunotherapeutic value of in various cancers, including LAML.

摘要

磷酸二酯酶4D相互作用蛋白（）与环磷酸腺苷特异性磷酸二酯酶4D相互作用，其异常表达促进血液系统恶性肿瘤、乳腺癌和松果体细胞瘤的发展。然而，目前尚无关于该蛋白与各种癌症之间关联的系统性泛癌分析。因此，本研究旨在阐明该蛋白在各种癌症中的潜在功能。基于多个公共数据库和在线网站，我们对该蛋白在各种癌症中进行了全面分析，包括差异表达、预后、基因变异、DNA甲基化和免疫情况。我们深入分析了该蛋白在急性髓系白血病（LAML）中的具体作用。结果表明，该蛋白在不同癌症中的表达存在差异，在肾嫌色细胞癌、急性髓系白血病、嗜铬细胞瘤和副神经节瘤、胸腺瘤以及葡萄膜黑色素瘤中，该蛋白具有潜在的预后价值。该蛋白的表达还与癌症中的基因变异、DNA甲基化、免疫细胞浸润以及免疫相关基因相关。功能富集分析表明，该蛋白在癌症中主要与免疫相关途径有关，在急性髓系白血病中，该蛋白主要与免疫球蛋白复合物、T细胞受体复合物以及免疫反应调节信号通路有关。我们的研究首次系统地揭示了该蛋白在包括急性髓系白血病在内的各种癌症中的潜在预后和免疫治疗价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/10473463/0217ccf173c3/j_med-2023-0782-fig008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/10473463/0bca2f42ac11/j_med-2023-0782-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/10473463/8affa7ed7c1e/j_med-2023-0782-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/10473463/7f3527c6b973/j_med-2023-0782-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/10473463/0f4b2e27715f/j_med-2023-0782-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/10473463/918e7a8f6cc9/j_med-2023-0782-fig005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/10473463/8ad0fd8794b4/j_med-2023-0782-fig006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/10473463/b91510b282f0/j_med-2023-0782-fig007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/10473463/0217ccf173c3/j_med-2023-0782-fig008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/10473463/0bca2f42ac11/j_med-2023-0782-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/10473463/8affa7ed7c1e/j_med-2023-0782-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/10473463/7f3527c6b973/j_med-2023-0782-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/10473463/0f4b2e27715f/j_med-2023-0782-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/10473463/918e7a8f6cc9/j_med-2023-0782-fig005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/10473463/8ad0fd8794b4/j_med-2023-0782-fig006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/10473463/b91510b282f0/j_med-2023-0782-fig007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/10473463/0217ccf173c3/j_med-2023-0782-fig008.jpg

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