Chen Jieying, Jin Junyan, Jiang Jun, Wang Yaping
Department of Cardiology of The Second Affiliated Hospital, School of Medicine Zhejiang University, Hangzhou, China.
Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, China.
Front Pharmacol. 2023 Aug 17;14:1194884. doi: 10.3389/fphar.2023.1194884. eCollection 2023.
Cardiovascular diseases (CVDs) are a group of diseases that have a major impact on global health and are the leading cause of death. A large number of chemical base modifications in ribonucleic acid (RNA) are associated with cardiovascular diseases. A variety of ribonucleic acid modifications exist in cells, among which adenosine deaminase-dependent modification is one of the most common ribonucleic acid modifications. Adenosine deaminase acting on ribonucleic acid 1 (Adenosine deaminase acting on RNA 1) is a widely expressed double-stranded ribonucleic acid adenosine deaminase that forms inosine (A-to-I) by catalyzing the deamination of adenosine at specific sites of the target ribonucleic acid. In this review, we provide a comprehensive overview of the structure of Adenosine deaminase acting on RNA 1 and summarize the regulatory mechanisms of ADAR1-mediated ribonucleic acid editing in cardiovascular diseases, indicating Adenosine deaminase acting on RNA 1 as a promising therapeutic target in cardiovascular diseases.
心血管疾病（CVDs）是一组对全球健康有重大影响的疾病，也是主要的死亡原因。核糖核酸（RNA）中的大量化学碱基修饰与心血管疾病有关。细胞中存在多种核糖核酸修饰，其中腺苷脱氨酶依赖性修饰是最常见的核糖核酸修饰之一。作用于核糖核酸1的腺苷脱氨酶（Adenosine deaminase acting on RNA 1）是一种广泛表达的双链核糖核酸腺苷脱氨酶，通过催化靶核糖核酸特定位点的腺苷脱氨形成次黄嘌呤（A-to-I）。在本综述中，我们全面概述了作用于RNA 1的腺苷脱氨酶的结构，并总结了ADAR1介导的核糖核酸编辑在心血管疾病中的调控机制，表明作用于RNA 1的腺苷脱氨酶是心血管疾病中一个有前景的治疗靶点。
