Golsorkhi Haide, Qorbani Mostafa, Sabbaghzadegan Saeideh, Dadmehr Majid
Department of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran.
Student Research Committee, Iran University of Medical Sciences, Tehran, Iran.
Avicenna J Phytomed. 2023 Jul-Aug;13(4):338-353. doi: 10.22038/AJP.2022.21115.
This study was performed to provide an updated systematic review of herbal medicines and phytochemicals used for treatment of the pediatric patients with attention- deficit/hyperactivity disorder (ADHD).
International electronic databases, including Scopus, PubMed, ScienceDirect, and Google Scholar were investigated from 1st January 2000 to late October 2021. Interventional studies published in English language, including randomized controlled trials (RCTs) or open-label clinical studies, which evaluated the effect of herbal medicines and phytochemicals on pediatric ADHD were included in this review.
Fifteen studies met the inclusion criteria. Several pieces of evidence support the efficacy of L. and Pycnogenol; mainly inconclusive evidence could be found for L L., and ginseng. The results showed that while L. was ineffective for ADHD, L L, and (Mill.) D.A.Webb had similar efficacy compared to methylphenidate (MPH).
A number of herbal medicines appear to be relatively safe and provide potential efficacy in amelioration of ADHD. However, due to lack of adequate reports of RCTs, no definitely specific recommendations could been made so far.
本研究旨在对用于治疗儿童注意力缺陷多动障碍（ADHD）的草药和植物化学物质进行最新的系统评价。
对2000年1月1日至2021年10月下旬的国际电子数据库，包括Scopus、PubMed、ScienceDirect和谷歌学术进行了检索。纳入以英文发表的干预性研究，包括评估草药和植物化学物质对儿童ADHD影响的随机对照试验（RCT）或开放标签临床研究。
15项研究符合纳入标准。有多项证据支持左旋肉碱和碧萝芷的疗效；对于刺蒺藜、南非醉茄和人参，主要是不确定的证据。结果表明，虽然左旋肉碱对ADHD无效，但刺蒺藜、南非醉茄和（密花豆）D.A.韦伯与哌甲酯（MPH）相比具有相似的疗效。
一些草药似乎相对安全，对改善ADHD具有潜在疗效。然而，由于RCT的报告不足，目前尚无明确的具体建议。
