Urina-Jassir Manuel, Patiño-Aldana Andrés Felipe, Herrera-Parra Lina Johana, Hernández Vargas Juliana Alexandra, Trujillo-Cáceres Silvia Juliana, Valbuena-García Ana María, Acuña-Merchán Lizbeth, Urina-Jassir Daniela, Urina-Triana Miguel
Departamento de Investigación Clínica, Fundación del Caribe para la Investigación Biomédica, Barranquilla, Colombia.
Department of Medicine, Boston Medical Center and Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Int J Cardiol Cardiovasc Risk Prev. 2023 Aug 17;18:200205. doi: 10.1016/j.ijcrp.2023.200205. eCollection 2023 Sep.
People living with HIV (PLWHIV) are at a higher risk of developing coronary artery disease (CAD). We aimed to assess the factors associated with CAD among PLWHIV in Colombia.
We conducted a retrospective cohort study based on adults newly diagnosed with HIV, reported to the Colombian HIV/AIDS registry from 2018 to 2021. Baseline demographic and clinical characteristics were compared by age (<50 and ≥ 50 years). Our main outcome was the presence of CAD. Logistic regression models were used to assess the association between traditional and HIV-related factors with CAD. These associations were also evaluated in stratified models by age. Effect measures were odds ratios (OR) and their 95% confidence intervals.
Among 36,483 PLWHIV, the frequency of CAD was 0.53% (n = 196). There was a high prevalence of impaired fasting glucose/diabetes mellitus (12.62%), overweight/obesity (27.79%), elevated LDL-c (86.69%), and hypertriglyceridemia (72.76%). Factors associated with CAD included male gender (OR: 2.01, 95% CI: 1.12-3.58), age ≥50 years (OR: 4.96, 95% CI: 3.29-7.45), lipoatrophy or lipodystrophy (OR 5.12, 95% CI: 1.12-23.33), AIDS-defining conditions (OR: 1.83, 95% CI: 1.07-3.12), obesity (OR: 2.95, 95% CI: 1.69-5.10), diabetes mellitus (OR: 2.50, 95% CI: 1.25-4.97), and renal impairment (OR: 3.15, 95% CI: 1.83-5.42).
Traditional CAD risk factors are common in PLWHIV. There were traditional and disease-specific factors associated with increased odds of CAD. These findings may aid clinicians and decision-makers in reducing the impact of CAD in PLWHIV.
人类免疫缺陷病毒感染者（PLWHIV）患冠状动脉疾病（CAD）的风险更高。我们旨在评估哥伦比亚PLWHIV中与CAD相关的因素。
我们基于2018年至2021年向哥伦比亚艾滋病毒/艾滋病登记处报告的新诊断为艾滋病毒的成年人进行了一项回顾性队列研究。根据年龄（<50岁和≥50岁）比较基线人口统计学和临床特征。我们的主要结局是CAD的存在。使用逻辑回归模型评估传统因素和与艾滋病毒相关的因素与CAD之间的关联。这些关联也在按年龄分层的模型中进行评估。效应量为比值比（OR）及其95%置信区间。
在36483名PLWHIV中，CAD的发生率为0.53%（n = 196）。空腹血糖受损/糖尿病（12.62%）、超重/肥胖（27.79%）、低密度脂蛋白胆固醇升高（86.69%）和高甘油三酯血症（72.76%）的患病率很高。与CAD相关的因素包括男性（OR：2.01，95%CI：1.12 - 3.58）、年龄≥50岁（OR：4.96，95%CI：3.29 - 7.45）、脂肪萎缩或脂肪代谢障碍（OR 5.12，95%CI：1.12 - 23.33）、艾滋病界定疾病（OR：1.83，95%CI：1.07 - 3.12）、肥胖（OR：2.95，95%CI：1.69 - 5.10）、糖尿病（OR：2.50，95%CI：1.25 - 4.97）和肾功能损害（OR：3.15，95%CI：1.83 - 5.42）。
传统的CAD危险因素在PLWHIV中很常见。存在与CAD发生几率增加相关的传统因素和疾病特异性因素。这些发现可能有助于临床医生和决策者降低CAD对PLWHIV的影响。
