Schoinohoriti Ourania, Tsami Christina, Karathanasi Vasiliki, Kolomvos Nikolaos
Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Athens, Athens, GRC.
Department of Dermatology, Evangelismos General Hospital, Athens, GRC.
Cureus. 2023 Aug 2;15(8):e42840. doi: 10.7759/cureus.42840. eCollection 2023 Aug.
Ameloblastoma is a benign odontogenic tumor of epithelial origin that exhibits a locally aggressive behavior with a high level of recurrence and multiple factors involved in its molecular pathogenesis. This article is a case report of a 46-year-old male patient suffering from a progressively enlarging tumor of the anterior mandible that caused gradual expansion of the lingual cortical plate and root displacement without resorption of the involved teeth. Incisional biopsy was consistent with "conventional" ameloblastoma, showing a mixed pattern of both the follicular and acanthomatous subtypes. This diagnosis was corroborated through a histopathological examination of the resected specimen. The patient was submitted to en bloc resection (marginal mandibulectomy) with preservation of the lower mandibular border; dental rehabilitation was achieved through a removable prosthesis. He remains disease-free for 5.5 years postoperatively and is highly satisfied with mastication and speech. The objective of this report is to highlight a relatively rare histopathological presentation of the "conventional" ameloblastoma, involving a site not commonly affected by ameloblastomas, the anterior mandible and crossing the midline, in a relatively young male patient.
成釉细胞瘤是一种起源于上皮的良性牙源性肿瘤，具有局部侵袭性，复发率高，其分子发病机制涉及多种因素。本文报告一例46岁男性患者，患有下颌前部逐渐增大的肿瘤，导致舌侧皮质骨板逐渐扩张和牙根移位，而受累牙齿无吸收。切开活检结果符合“传统型”成釉细胞瘤，显示为滤泡型和棘皮瘤型的混合模式。通过对切除标本的组织病理学检查证实了这一诊断。患者接受了整块切除（下颌骨边缘切除术）并保留了下颌下缘；通过可摘义齿实现了牙齿修复。术后5.5年他仍无疾病复发，对咀嚼和言语功能非常满意。本报告的目的是强调“传统型”成釉细胞瘤一种相对罕见的组织病理学表现，该表现发生在相对年轻的男性患者中，累及下颌前部这个成釉细胞瘤不常累及的部位且肿瘤跨越中线。
