McClary Andrew C, West Robert B, McClary Ashley C, Pollack Jonathan R, Fischbein Nancy J, Holsinger Christopher F, Sunwoo John, Colevas A Dimitrios, Sirjani Davud
Department of Pathology, Stanford University, 300 Pasteur Drive, Lane 235, Stanford, CA, 94305-5324, USA.
Department of Pediatrics, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA.
Eur Arch Otorhinolaryngol. 2016 Jul;273(7):1649-61. doi: 10.1007/s00405-015-3631-8. Epub 2015 Apr 30.
Ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. The current mainstay of treatment is wide local excision with appropriate margins and immediate reconstruction. Here we review the ameloblastoma literature, using the available evidence to highlight the change in management over the past several decades. In addition, we explore the recent molecular characterization of these tumors which may point towards new potential avenues of personalized treatment.
成釉细胞瘤是一种罕见的下颌骨和上颌骨牙源性肿瘤，有多种组织学变异型，若治疗不当复发率很高。目前的主要治疗方法是进行广泛的局部切除并保证切缘合适，然后立即进行重建。在此，我们回顾成釉细胞瘤的相关文献，利用现有证据强调过去几十年来治疗方法的变化。此外，我们还探讨了这些肿瘤最近的分子特征，这可能为个性化治疗指明新的潜在途径。
