Abdullah Mohd Faizal, Hamzah Muhd Amir Ridzuan, Fauzi Fattirah Auni, Mat Zin Anani Aila, Yusoff Bazli M
Oral and Maxillofacial Surgery, Hospital Universiti Sains Malaysia, Kota Bharu, MYS.
Oral and Maxillofacial Surgery, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, Kota Bharu, MYS.
Cureus. 2023 Aug 1;15(8):e42825. doi: 10.7759/cureus.42825. eCollection 2023 Aug.
Necrotizing sialometaplasia refers to a benign, uncommon, and self-limiting inflammatory reaction concerning the salivary gland tissue, which both clinically and histologically may be easily mistaken for mucoepidermoid carcinoma or squamous cell carcinoma. This may cause irrelevant surgical intervention. Minor salivary glands are the most commonly affected salivary gland, with the hard palate being the most usual site. However, it can involve the other areas in which salivary gland tissue is present in the other oral subsites and pharyngeal areas. Due to the lack of knowledge about this entity and its histological similarities with carcinomas, particularly mucoepidermoid carcinoma, the differential diagnosis of this lesion is difficult. Local ischemia is thought to be the primary cause, leading to the pathogenesis of necrotizing sialometaplasia, and the infiltration of local anesthesia following dental procedures at the palatal region is the leading cause.
坏死性涎腺化生是指一种涉及涎腺组织的良性、罕见且自限性的炎症反应，在临床和组织学上都可能容易被误诊为黏液表皮样癌或鳞状细胞癌。这可能导致不必要的手术干预。小涎腺是最常受累的涎腺，硬腭是最常见的部位。然而，它也可累及其他存在涎腺组织的口腔亚部位和咽部区域。由于对该实体缺乏了解以及它与癌（尤其是黏液表皮样癌）在组织学上的相似性，该病变的鉴别诊断很困难。局部缺血被认为是主要病因，导致坏死性涎腺化生的发病机制，而腭部区域牙科操作后局部麻醉药的浸润是主要原因。
