Joseph Daren Kumar, Mat Ludin Arimi Fitri, Ibrahim Farah Wahida, Ahmadazam Amalina, Che Roos Nur Aishah, Shahar Suzana, Rajab Nor Fadilah
Center for Healthy Ageing and Wellness (H-CARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Center for Toxicology and Health Risk Studies (CORE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Front Physiol. 2023 Aug 16;14:1216948. doi: 10.3389/fphys.2023.1216948. eCollection 2023.
Studies have shown that exercise increases angiogenesis and perfusion in the hippocampus, activates neurogenesis in the dentate gyrus and increases synaptic plasticity, as well as increases the complexity and number of dendritic spines, all of which promote memory function and protect against cognitive decline. Flavonoids are gaining attention as antioxidants in health promotion due to their rich phenolic content, particularly for their modulating role in the treatment of neurodegenerative diseases. Despite this, there has been no comprehensive review of cognitive improvement supplemented with flavonoid and prescribed with exercise or a combination of the two interventions has been conducted. The purpose of this review is to determine whether a combined intervention produces better results when given together than when given separately. Relevant articles assessing the effect of physical exercise, flavonoid or in combination on cognitive related biomarkers and neurobehavioral assessments within the timeline of January 2011 until June 2023 were searched using three databases; PubMed, PROQUEST and SCOPUS. A total of 705 articles were retrieved and screened, resulting in 108 studies which are in line with the objective of the current study were included in the analysis. The selected studies have shown significant desired effect on the chosen biomarkers and neurobehavioral assessments. identifier: [CRD42021271001].
研究表明，运动可增加海马体中的血管生成和灌注，激活齿状回中的神经发生，增强突触可塑性，还能增加树突棘的复杂性和数量，所有这些都有助于改善记忆功能并预防认知能力下降。黄酮类化合物因其丰富的酚类成分，作为抗氧化剂在促进健康方面受到关注，特别是其在治疗神经退行性疾病中的调节作用。尽管如此，尚未有关于补充黄酮类化合物并结合运动或两种干预措施联合使用对认知改善情况的全面综述。本综述的目的是确定联合干预与单独干预相比是否能产生更好的效果。我们使用三个数据库（PubMed、PROQUEST和SCOPUS）检索了2011年1月至2023年6月期间评估体育锻炼、黄酮类化合物或两者联合对认知相关生物标志物和神经行为评估影响的相关文章。共检索并筛选出705篇文章，其中108项研究符合本研究目的并纳入分析。所选研究对选定的生物标志物和神经行为评估显示出显著的预期效果。标识符：[CRD42021271001]
