Hao Linlin, Zhang Lihui, Xu Chuanjie, Jiang Min, Zhu Geyi, Guo Jie
Department of Tumor Radiotherapy, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
Department of Gynaecology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
Oncol Lett. 2023 Aug 17;26(4):428. doi: 10.3892/ol.2023.14014. eCollection 2023 Oct.
Multiple primary malignant neoplasms (MPMN) are defined as two or more primary malignancies diagnosed in an individual. There is no association between these cancers, which can be classified into synchronous and heterochronous cancers depending on the time of diagnosis. The present study presented a rare case of bilateral breast, endometrial, cervical and ovarian cancers. Through thorough physical examination, pathology and immunohistochemistry, it could be determined that bilateral breast, endometrial and cervical cancers were primary malignant tumors and that ovarian cancer cannot be excluded as a result of metastasis. the present study also summarized the definitions, risk factors, prevalence characteristics, diagnostic ideas and treatment options for MPMN by reviewing the literature.
多原发性恶性肿瘤(MPMN)定义为在个体中诊断出的两种或更多种原发性恶性肿瘤。这些癌症之间没有关联,根据诊断时间可分为同时性癌和异时性癌。本研究报告了一例罕见的双侧乳腺癌、子宫内膜癌、宫颈癌和卵巢癌病例。通过全面的体格检查、病理检查和免疫组化检查,可以确定双侧乳腺癌、子宫内膜癌和宫颈癌为原发性恶性肿瘤,而卵巢癌不能排除为转移所致。本研究还通过文献复习总结了MPMN的定义、危险因素、流行特征、诊断思路和治疗选择。