Asaad Amira, Barron Marina, Rasheed Noreen, Idaewor Philip, Saad Abdalla Al-Zawi Abdalla
Plastic and Reconstructive Surgery, University College of Medical Sciences, London, GBR.
Emergency Department, South West Acute Hospital, Enniskillen, GBR.
Cureus. 2021 Feb 12;13(2):e13314. doi: 10.7759/cureus.13314.
Any two or more primary malignant tumors, in which each tumor is not an extension, recurrence, or metastasis of the other lesion, are defined or described as multiple primary malignant neoplasms (MPMN). These tumors are increasingly diagnosed despite their rare occurrence rate. The term synchronous tumors is applied if two different tumors originating in the same patient are detected at the same time or within six months; if the second tumor is detected beyond six months, it is called metachronous. Aetiological factors that may predispose patients to MPMNs have been grouped into three broad categories: familial cancer syndromes and other genetic susceptibility factors, common exposures (e.g. tobacco), and carcinogenic effects of cancer treatment. The likelihood of missing asymptomatic synchronous tumors at the time of diagnosis is due to a lack of definitively set guidelines for synchronous tumors. Studying every individual case may aid us in understanding disease biology, developing diagnostic guidelines, and establishing patient-specific management strategies. We present a case report of synchronous breast and colonic cancer in a female patient.
任何两个或更多原发性恶性肿瘤，其中每个肿瘤都不是其他病变的扩展、复发或转移，被定义或描述为多原发性恶性肿瘤（MPMN）。尽管其发生率很低，但这类肿瘤的诊断越来越多。如果在同一患者中同时或在六个月内检测到两种不同的肿瘤，则称其为同时性肿瘤；如果第二个肿瘤在六个月后被检测到，则称为异时性肿瘤。可能使患者易患MPMN的病因因素可分为三大类：家族性癌症综合征和其他遗传易感性因素、常见暴露（如烟草）以及癌症治疗的致癌作用。由于缺乏针对同时性肿瘤的确切设定指南，在诊断时漏诊无症状同时性肿瘤的可能性很大。研究每一个病例可能有助于我们了解疾病生物学、制定诊断指南以及建立针对患者的管理策略。我们报告一例女性患者同时发生乳腺癌和结肠癌的病例。
