Department of Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Division of Infectious Diseases, Department of Medicine, Houston Methodist Hospital, Houston, Texas, USA.
J Med Virol. 2023 Sep;95(9):e29078. doi: 10.1002/jmv.29078.
A man in his mid-30s presented with 1 week of painful, progressive, and confluent tongue and chin ulcerations. Swabs of the lesions were detected positive for monkeypox (mpox) DNA by polymerase chain reaction. During hospitalization, he received a diagnosis of human immunodeficiency virus-1. Due to severe oral pain, the patient was treated with intravenous tecovirimat 200 mg every 12 h for 4 days with remarkable improvement in lingual lesions. He completed a total 14-day course with oral tecovirimat. Our patient's clinical progress contributes to the data available for the potential efficacy of intravenous tecovirimat for mpox infection in humans.
一名 30 多岁的男性出现了 1 周的舌和下巴疼痛、进行性、融合性溃疡。病变拭子的聚合酶链反应检测到猴痘（mpox）DNA 呈阳性。住院期间，他被诊断为人免疫缺陷病毒-1。由于严重的口腔疼痛，患者接受了静脉注射替科韦马 200mg，每 12 小时一次，共 4 天，舌部病变明显改善。他完成了总共 14 天的口服替科韦马疗程。我们患者的临床进展为静脉注射替科韦马治疗人类猴痘感染的潜在疗效提供了可用数据。
