School of Public Health, Wuhan University, Wuhan, P. R. China.
Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Food Funct. 2023 Sep 19;14(18):8597-8603. doi: 10.1039/d3fo01758c.
Evidence on the association between dietary nutrient-wide intake and cardiovascular disease (CVD) is inconclusive. Therefore, we systematically assessed the association between dietary intake of 29 nutrients and CVD risk using a nutrient-wide association study. Data were obtained from 7878 Chinese adults participating in the China Health and Nutrition Survey (CHNS) wave 2004-2015. We estimated the association of 29 nutrients with CVD risk. Significant findings were replicated in the National Health and Nutrition Examination Survey (NHANES). Four nutrients (selenium, vitamin A, carotenoids, and total protein) were significantly associated with CVD risk in the CHNS. The hazard ratio (HR) and 95% confidence interval (CI) for nutrient intake in the third tertile compared to the first tertile were 0.68 (0.51-0.90), 0.70 (0.54-0.91), 0.64 (0.50-0.83), and 0.54 (0.38-0.77), respectively. In the NHANES replication, selenium maintained a similar direction and strength of association, while the other nutrients were not replicated successfully. Our results provide support for a negative association between selenium intake and CVD risk, while the association of vitamin A, carotenoids and protein with CVD warrants further studies to confirm.
关于饮食营养素摄入与心血管疾病（CVD）之间的关联，目前尚无定论。因此，我们使用营养素广泛关联研究系统地评估了 29 种营养素的饮食摄入与 CVD 风险之间的关联。数据来自于 7878 名参加中国健康与营养调查（CHNS）2004-2015 年波次的中国成年人。我们估计了 29 种营养素与 CVD 风险之间的关联。在国家健康与营养调查（NHANES）中对显著发现进行了复制。CHNS 中，有 4 种营养素（硒、维生素 A、类胡萝卜素和总蛋白）与 CVD 风险显著相关。与第一 tertile 相比，第三 tertile 营养素摄入的危险比（HR）和 95%置信区间（CI）分别为 0.68（0.51-0.90）、0.70（0.54-0.91）、0.64（0.50-0.83）和 0.54（0.38-0.77）。在 NHANES 的复制中，硒保持了相似的关联方向和强度，而其他营养素则没有成功复制。我们的研究结果为硒摄入与 CVD 风险之间的负相关提供了支持，而维生素 A、类胡萝卜素和蛋白质与 CVD 的关联则需要进一步研究来证实。
