Department of Neurology, Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei, China.
Department of Neurology, Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei, China.
J Affect Disord. 2023 Feb 1;322:84-90. doi: 10.1016/j.jad.2022.11.013. Epub 2022 Nov 10.
Few observational studies have investigated the association of dietary antioxidant intake with post-stroke depression (PSD) risk. We used the cross-sectional and longitudinal design to investigate the independent and joint associations between dietary antioxidant intake and PSD risk and all-cause mortality.
Participants from the 2005-2014 National Health and Nutrition Examination Survey (NHANES) aged 20 years and older with stroke were included. Logistic and Cox regression analyses were used to assess the associations of dietary antioxidant intake, including vitamin A, vitamin C, vitamin E, zinc, selenium, and carotenoids, and composite dietary antioxidant index (CDAI) with PSD risk and all-cause mortality.
The highest quartile of dietary vitamin A (OR: 0.54, 95%CI: 0.32, 0.92), total carotenoids (OR: 0.56, 95%CI: 0.34, 0.94), and selenium intake (OR: 0.53, 95%CI: 0.31, 0.90) were associated with decreased PSD risk compared with those in the lowest quartile. The results showed a negative association between CDAI and PSD risk, with the lowest OR in the third quartiles (OR: 0.49, 95%CI: 0.30, 0.83). Furthermore, the highest quartile of dietary vitamin A (HR: 0.63, 95%CI: 0.45, 0.89), vitamin E (HR: 0.69, 95%CI: 0.48, 0.99), zinc (HR: 0.57, 95%CI: 0.40, 0.81), selenium (HR: 0.64, 95%CI: 0.46, 0.90), and total carotenoids (HR: 0.66, 95%CI: 0.47, 0.92) intake and CDAI (HR: 0.56, 95%CI: 0.39, 0.81) were associated with decreased all-cause mortality compared with those in the lowest quartile.
Increased intake of dietary antioxidant may protect from depressive symptoms and improve the prognosis of stroke patients.
很少有观察性研究调查饮食抗氧化剂摄入与中风后抑郁（PSD）风险之间的关系。我们使用横断面和纵向设计来研究饮食抗氧化剂摄入与 PSD 风险和全因死亡率之间的独立和联合关联。
本研究纳入了年龄在 20 岁及以上且患有中风的 2005-2014 年全国健康与营养调查（NHANES）参与者。使用逻辑回归和 Cox 回归分析评估了饮食抗氧化剂摄入，包括维生素 A、维生素 C、维生素 E、锌、硒和类胡萝卜素，以及复合饮食抗氧化指数（CDAI）与 PSD 风险和全因死亡率之间的关系。
与最低四分位数相比，饮食中维生素 A（OR：0.54，95%CI：0.32，0.92）、总类胡萝卜素（OR：0.56，95%CI：0.34，0.94）和硒摄入（OR：0.53，95%CI：0.31，0.90）最高四分位数与 PSD 风险降低相关。结果表明，CDAI 与 PSD 风险呈负相关，第三四分位数的 OR 最低（OR：0.49，95%CI：0.30，0.83）。此外，饮食中维生素 A（HR：0.63，95%CI：0.45，0.89）、维生素 E（HR：0.69，95%CI：0.48，0.99）、锌（HR：0.57，95%CI：0.40，0.81）、硒（HR：0.64，95%CI：0.46，0.90）和总类胡萝卜素（HR：0.66，95%CI：0.47，0.92）摄入以及 CDAI（HR：0.56，95%CI：0.39，0.81）与全因死亡率降低相关。
增加饮食抗氧化剂的摄入可能有助于预防抑郁症状并改善中风患者的预后。
