Kimura G, Van Stone J C, Bauer J H
Am J Kidney Dis. 1986 Oct;8(4):253-6. doi: 10.1016/s0272-6386(86)80035-x.
The amount of sodium removed by hemodialysis was estimated, without using radioisotopes, as the change in total osmotically active cations, which is the product of the serum sodium concentration and urea-space. The extracellular and total body fluid volumes were measured using 35SO4 and 3H2O, respectively, in five stable hemodialysis patients under four different conditions. Urea-space determined, based on urea kinetics, was consistent with total body fluid volume measured by 3H2O. The amount of sodium removal, estimated as the change in the product of the serum (Na+) and urea-space, was equal to the change in the sodium content, which is the product of the serum (Na+) and extracellular fluid volume measured by 35SO4. Sodium removal may be divided into two components, diffusion and ultrafiltration.
在不使用放射性同位素的情况下，通过血液透析清除的钠量被估计为总渗透活性阳离子的变化量，其为血清钠浓度与尿素分布容积的乘积。在四种不同条件下，分别使用35SO4和3H2O对五名稳定的血液透析患者测量细胞外液和总体液量。基于尿素动力学测定的尿素分布容积与通过3H2O测量的总体液量一致。估计为血清（Na+）与尿素分布容积乘积变化量的钠清除量，等于钠含量的变化量，即血清（Na+）与通过35SO4测量的细胞外液量的乘积。钠清除可分为两个部分，即扩散和超滤。
