Kimura G, Gotch F A
Int J Artif Organs. 1984 Nov;7(6):331-6.
Changes in the serum Na+ concentration and transcellular body fluid distribution during the interdialytic period were simulated as functions of body weight gain assuming that the effective extracellular osmolality consists only of sodium. Our model shows that these changes are mainly determined by the relative ratio between sodium intake and weight gain in this period. If the sodium intake-to-net fluid intake ratio is equal to the postdialytic serum [Na+], neither changes in serum [Na+] nor transcellular fluid shifts occur. When sodium intake is relatively greater than the net water intake, serum [Na+] is increased and transcellular fluid shifts will occur out of the cells. On the other hand, when the net water intake is relatively greater than the sodium intake, serum [Na+] is decreased and fluid is distributed to both the intracellular and extracellular compartments. The combined application of our models for both the intradialytic interval described previously and the interdialytic interval described here is very useful in quantitatively analyzing the overall sodium and water metabolism in dialyzed patients.
假设有效细胞外渗透压仅由钠构成，将透析间期血清钠浓度和细胞间液分布的变化模拟为体重增加的函数。我们的模型表明，这些变化主要由该时期钠摄入量与体重增加之间的相对比例决定。如果钠摄入量与净液体摄入量之比等于透析后血清[Na⁺]，则血清[Na⁺]和细胞间液转移均不会发生。当钠摄入量相对大于净水量时，血清[Na⁺]升高，细胞间液将从细胞内移出。另一方面，当净水量相对大于钠摄入量时，血清[Na⁺]降低，液体分布于细胞内和细胞外间隙。将我们之前描述的透析期模型与此处描述的透析间期模型联合应用，对于定量分析透析患者的总体钠和水代谢非常有用。
