Yancheng Institute of Technology, P.O. Box No. 211 Jianjun Road, Yancheng, 224051, Jiangsu Province, China.
Jiangsu Province Engineering Research Center of Intelligent Environmental Protection Equipment, Yancheng, 224051, Jiangsu Province, China.
Environ Sci Pollut Res Int. 2023 Oct;30(46):102212-102221. doi: 10.1007/s11356-023-29631-1. Epub 2023 Sep 4.
This investigation explored the association between indoor environmental factors and childhood asthma in Yancheng, China. Asthma case (201 children with recurrent asthma) and control cohorts (242 healthy subjects) were recruited from a Traditional Chinese Medical (TCM) Hospital in Yancheng city, based on the results of an ISAAC questionnaire. Questionnaires regarding environmental risk factors were completed by the child's primary caregivers. To compare data on environmental VOCs and formaldehyde contents between asthma and control cohorts, we passively conducted a 10-day indoor and outdoor sampling. Breastfeeding was a major protective indoor environmental factor for recurrent asthma (adjusted odds ratio [aOR]: 0.368, 95% confidence interval [CI]: 0.216-0.627). Our analysis revealed that childhood recurrent asthma was intricately linked to a family history of asthma. Recurrent asthma was also associated with passive smoking [aOR2.115 (95%-CI 1.275-3.508)]. Analogous correlations were observed between household renovation or new furniture introduction and recurrent asthma [aOR3.129(95%-CI1.542-6.347)]. Benzene and formaldehyde were present in all examined homes. Enhanced benzene and formaldehyde concentrations were strongly evident among asthma versus control cohorts, and they were strongly correlated with augmented recurrent asthma risk. Home environment heavily regulates incidences of childhood recurrent asthma. Hence, actions against the indoor environmental risk factors described in this study may assist in the prevention of recurrent asthma among children.
本研究旨在探讨中国盐城室内环境因素与儿童哮喘之间的关系。哮喘病例（201 例复发性哮喘儿童）和对照组（242 例健康儿童）均来自盐城市一家中医院，根据 ISAAC 问卷调查结果进行招募。环境危险因素调查问卷由儿童的主要照顾者填写。为了比较哮喘组和对照组环境 VOCs 和甲醛含量的数据，我们进行了为期 10 天的室内外被动采样。母乳喂养是复发性哮喘的主要保护室内环境因素（调整后的优势比[aOR]：0.368，95%置信区间[CI]：0.216-0.627）。我们的分析表明，儿童复发性哮喘与哮喘家族史密切相关。复发性哮喘还与被动吸烟有关[aOR2.115（95%CI 1.275-3.508)]。家庭装修或新家具引入与复发性哮喘之间也存在类似的相关性[aOR3.129（95%CI 1.542-6.347)]。所有检测的家庭都存在苯和甲醛。与对照组相比，哮喘组的苯和甲醛浓度明显升高，且与复发性哮喘风险的增加呈强相关。家庭环境对儿童复发性哮喘的发病率有很大影响。因此，针对本研究中描述的室内环境危险因素采取行动，可能有助于预防儿童复发性哮喘。
