Cascella Marco, Vitale Vincenzo Norman, Mariani Fabio, Iuorio Manuel, Cutugno Francesco
Department of Anesthesia and Pain Medicine, Istituto Nazionale Tumori, IRCCS - Fondazione G Pascale, Naples, Italy.
DIETI, University of Naples "Federico II", Naples, Italy.
Scand J Pain. 2023 Sep 5;23(4):638-645. doi: 10.1515/sjpain-2023-0011. Print 2023 Oct 26.
The Automatic Pain Assessment (APA) relies on the exploitation of objective methods to evaluate the severity of pain and other pain-related characteristics. Facial expressions are the most investigated pain behavior features for APA. We constructed a binary classifier model for discriminating between the absence and presence of pain through video analysis.
A brief interview lasting approximately two-minute was conducted with cancer patients, and video recordings were taken during the session. The Delaware Pain Database and UNBC-McMaster Shoulder Pain dataset were used for training. A set of 17 Action Units (AUs) was adopted. For each image, the OpenFace toolkit was used to extract the considered AUs. The collected data were grouped and split into train and test sets: 80 % of the data was used as a training set and the remaining 20 % as the validation set. For continuous estimation, the entire patient video with frame prediction values of 0 (no pain) or 1 (pain), was imported into an annotator (ELAN 6.4). The developed Neural Network classifier consists of two dense layers. The first layer contains 17 nodes associated with the facial AUs extracted by OpenFace for each image. The output layer is a classification label of "pain" (1) or "no pain" (0).
The classifier obtained an accuracy of ∼94 % after about 400 training epochs. The Area Under the ROC curve (AUROC) value was approximately 0.98.
This study demonstrated that the use of a binary classifier model developed from selected AUs can be an effective tool for evaluating cancer pain. The implementation of an APA classifier can be useful for detecting potential pain fluctuations. In the context of APA research, further investigations are necessary to refine the process and particularly to combine this data with multi-parameter analyses such as speech analysis, text analysis, and data obtained from physiological parameters.
自动疼痛评估(APA)依赖于利用客观方法来评估疼痛的严重程度以及其他与疼痛相关的特征。面部表情是APA中研究最多的疼痛行为特征。我们通过视频分析构建了一个用于区分疼痛有无的二元分类器模型。
对癌症患者进行了一次持续约两分钟的简短访谈,并在访谈过程中进行了视频录制。使用特拉华疼痛数据库和UNBC - 麦克马斯特肩部疼痛数据集进行训练。采用了一组17个动作单元(AU)。对于每张图像,使用OpenFace工具包提取所考虑的AU。收集到的数据被分组并分为训练集和测试集:80%的数据用作训练集,其余20%用作验证集。对于连续估计,将具有帧预测值为0(无疼痛)或1(疼痛)的整个患者视频导入注释器(ELAN 6.4)。所开发的神经网络分类器由两个密集层组成。第一层包含17个节点,与OpenFace为每张图像提取的面部AU相关联。输出层是“疼痛”(1)或“无疼痛”(0)的分类标签。
经过约400个训练轮次后,分类器的准确率达到了约94%。ROC曲线下面积(AUROC)值约为0.98。
本研究表明,使用从选定的AU开发的二元分类器模型可以成为评估癌症疼痛的有效工具。APA分类器的实施对于检测潜在的疼痛波动可能是有用的。在APA研究的背景下,有必要进一步研究以完善该过程,特别是将这些数据与语音分析、文本分析以及从生理参数获得的数据等多参数分析相结合。