Gustave Roussy, Départements de Médecine Oncologique, F-94805, Villejuif, France.
CESP, INSERM U1018, Université Paris-Saclay, Villejuif, France.
Oncologist. 2023 Oct 3;28(10):829-831. doi: 10.1093/oncolo/oyad248.
This editorial calls for a strategic shift in our approach to cancers of unknown primary (CUP), one that generates a comprehensive multidimensional portrait of cancer in patients with CUP, to model the biology at the individual level and identify the right therapeutic target accordingly. The framework of this approach is based on the integration of basic biology, biotechnologies, data sciences, clinical research, and social sciences.
这篇社论呼吁我们对不明原发癌（CUP）的治疗方法进行战略转变，这种方法能够全面多维地描绘 CUP 患者的癌症情况，以在个体水平上模拟生物学，并据此确定正确的治疗靶点。这种方法的框架基于基础生物学、生物技术、数据科学、临床研究和社会科学的整合。
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