Kahn J K
Am J Med. 1986 Oct;81(4):705-6. doi: 10.1016/0002-9343(86)90561-9.
A 84-year-old man was given nifedipine for control of angina pectoris. Acute psychosis with paranoid ideation developed soon after he began receiving the medication. All symptoms resolved with discontinuation of nifedipine. This is the second reported case of nifedipine-associated acute psychosis. Alternations in calcium-mediated neurotransmitter release, particularly dopamine, may be responsible. Clinicians should consider nifedipine when presented with a patient with acute psychosis.
一名84岁男性因控制心绞痛服用硝苯地平。在开始服用该药物后不久出现了伴有偏执观念的急性精神病。停用硝苯地平后所有症状均消失。这是第二例报告的与硝苯地平相关的急性精神病病例。钙介导的神经递质释放，尤其是多巴胺的变化可能是原因所在。当面对患有急性精神病的患者时，临床医生应考虑到硝苯地平。
