Hullett F J, Potkin S G, Levy A B, Ciasca R
Department of Psychiatry, University of California, Irvine.
Am J Psychiatry. 1988 Oct;145(10):1277-9. doi: 10.1176/ajp.145.10.1277.
Four cases are reported in which substantial depression was associated with the use of the calcium channel blocker nifedipine. In one instance, a patient became unresponsive to treatment with nortriptyline when nifedipine was introduced. In each case, the depression resolved following discontinuation of nifedipine. Possible mechanisms by which nifedipine may influence affective states are discussed.
本文报告了4例与使用钙通道阻滞剂硝苯地平相关的严重抑郁病例。其中1例患者在开始使用硝苯地平后对去甲替林治疗无反应。在每例病例中，停用硝苯地平后抑郁症状均得到缓解。文中讨论了硝苯地平可能影响情感状态的潜在机制。
