Niebyl J R, Witter F R
Am J Obstet Gynecol. 1986 Oct;155(4):747-9. doi: 10.1016/s0002-9378(86)80012-6.
Forty-six infants exposed to indomethacin in utero for treatment for preterm labor were compared with infants from two control groups. In one control group the next consecutive patient treated with a tocolytic agent was used, and the other control group was formed by picking the next consecutive patient matched by gestational age who did not receive any tocolytic agent. There was no significant difference in Apgar scores, birth weight, or gestational age in the three groups. The incidence of neonatal complications including hypocalcemia, hypoglycemia, respiratory distress syndrome, patient ductus arteriosus, sepsis, and neonatal mortality were not significantly different in the three groups. No cases of premature closure of the ductus arteriosus or persistent fetal circulation were seen.
将46例因早产接受宫内吲哚美辛治疗的婴儿与两个对照组的婴儿进行比较。在一个对照组中，使用下一个连续接受宫缩抑制剂治疗的患者，另一个对照组则选取下一个连续的、孕周匹配且未接受任何宫缩抑制剂治疗的患者。三组的阿氏评分、出生体重或孕周均无显著差异。三组中包括低钙血症、低血糖、呼吸窘迫综合征、动脉导管未闭、败血症和新生儿死亡率在内的新生儿并发症发生率无显著差异。未观察到动脉导管过早关闭或持续胎儿循环的病例。
