Zhang Qiang, Godfred K Tawiah, Zhang Yanjun, Wei Xiaochun, Chen Weiyi, Zhang Quanyou
College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, P. R. China.
Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, the Second Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan 030001, P. R. China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2023 Aug 25;40(4):638-644. doi: 10.7507/1001-5515.202301029.
Mechanical signal transduction are crucial for chondrocyte in response to mechanical cues during the growth, development and osteoarthritis (OA) of articular cartilage. Extracellular matrix (ECM) turnover regulates the matrix mechanical microenvironment of chondrocytes. Thus, understanding the mechanotransduction mechanisms during chondrocyte sensing the matrix mechanical microenvironment can develop effective targeted therapy for OA. In recent decades, growing evidences are rapidly advancing our understanding of the mechanical force-dependent cartilage remodeling and injury responses mediated by TRPV4 and PIEZOs. In this review, we highlighted the mechanosensing mechanism mediated by TRPV4 and PIEZOs during chondrocytes sensing mechanical microenvironment of the ECM. Additionally, the latest progress in the regulation of OA by inflammatory signals mediated by TRPV4 and PIEZOs was also introduced. These recent insights provide the potential mechanotheraputic strategies to target these channels and prevent cartilage degeneration associated with OA. This review will shed light on the pathogenesis of articular cartilage, searching clinical targeted therapies, and designing cell-induced biomaterials.
机械信号转导对于软骨细胞在关节软骨生长、发育和骨关节炎（OA）过程中响应机械信号至关重要。细胞外基质（ECM）周转调节软骨细胞的基质力学微环境。因此，了解软骨细胞感知基质力学微环境过程中的机械转导机制可为OA开发有效的靶向治疗方法。近几十年来，越来越多的证据迅速推进了我们对由TRPV4和PIEZOs介导的机械力依赖性软骨重塑和损伤反应的理解。在这篇综述中，我们重点介绍了软骨细胞感知ECM机械微环境过程中由TRPV4和PIEZOs介导的机械传感机制。此外，还介绍了由TRPV4和PIEZOs介导的炎症信号调节OA的最新进展。这些最新见解提供了靶向这些通道并预防与OA相关的软骨退变的潜在机械治疗策略。这篇综述将阐明关节软骨的发病机制，寻找临床靶向治疗方法，并设计细胞诱导生物材料。
