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2021年诺贝尔机械感觉转导奖。

2021 Nobel Prize for mechanosensory transduction.

作者信息

Martinac Boris

机构信息

Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute and St. Vincent's Medical School, Darlinghurst, NSW 2010 Australia.

出版信息

Biophys Rev. 2022 Feb 19;14(1):15-20. doi: 10.1007/s12551-022-00935-9. eCollection 2022 Feb.

DOI:10.1007/s12551-022-00935-9
PMID:35340591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8921412/
Abstract

Written by someone who has worked in the mechanobiology field for close to 40 years, this commentary describes some historical background to the recent award of one-half of the Nobel Prize for Physiology or Medicine to Ardem Patapoutian for his discovery of the family of mechanosensitive Piezo ion channels, which function as mechanoreceptors feeling the environment in senses such as touch, pain, and proprioception.

摘要

这篇评论由一位在力学生物学领域工作了近40年的人士撰写,描述了最近诺贝尔生理学或医学奖一半授予阿尔登·帕塔普蒂安的一些历史背景,他发现了机械敏感的Piezo离子通道家族,这些通道作为机械感受器,在触觉、疼痛和本体感觉等感觉中感知环境。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/252a/8921412/37d484b809b0/12551_2022_935_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/252a/8921412/2921464cb36b/12551_2022_935_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/252a/8921412/7a89055009a7/12551_2022_935_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/252a/8921412/e8a3d84a99ae/12551_2022_935_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/252a/8921412/37d484b809b0/12551_2022_935_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/252a/8921412/2921464cb36b/12551_2022_935_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/252a/8921412/7a89055009a7/12551_2022_935_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/252a/8921412/e8a3d84a99ae/12551_2022_935_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/252a/8921412/37d484b809b0/12551_2022_935_Fig4_HTML.jpg

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