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Final approval for corticosteroids in severe CAP? For sure, in septic shock.

作者信息

Martin-Loeches Ignacio, Nagavci Blin, Torres Antoni

机构信息

Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), Leinster, Dublin, D08NYH1, Ireland.

Independent Researcher - Methodologist, I. Boletini 850000, Gjakova, Kosovo.

出版信息

Crit Care. 2023 Sep 4;27(1):342. doi: 10.1186/s13054-023-04613-4.

DOI:10.1186/s13054-023-04613-4
PMID:37667250
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10476391/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c4f/10476391/47fd3f403ed6/13054_2023_4613_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c4f/10476391/154ca5a8271a/13054_2023_4613_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c4f/10476391/6627d4260289/13054_2023_4613_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c4f/10476391/52f06561137e/13054_2023_4613_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c4f/10476391/c009ec6f8c15/13054_2023_4613_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c4f/10476391/565429979e87/13054_2023_4613_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c4f/10476391/812a5d66c785/13054_2023_4613_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c4f/10476391/47fd3f403ed6/13054_2023_4613_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c4f/10476391/154ca5a8271a/13054_2023_4613_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c4f/10476391/6627d4260289/13054_2023_4613_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c4f/10476391/52f06561137e/13054_2023_4613_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c4f/10476391/c009ec6f8c15/13054_2023_4613_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c4f/10476391/565429979e87/13054_2023_4613_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c4f/10476391/812a5d66c785/13054_2023_4613_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c4f/10476391/47fd3f403ed6/13054_2023_4613_Fig7_HTML.jpg

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1
Final approval for corticosteroids in severe CAP? For sure, in septic shock.皮质类固醇用于重症社区获得性肺炎的最终批准？当然，用于感染性休克。
Crit Care. 2023 Sep 4;27(1):342. doi: 10.1186/s13054-023-04613-4.
2
Corticosteroids for septic shock.用于感染性休克的皮质类固醇。
N Engl J Med. 1985 Feb 21;312(8):509-12.
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No evidence that corticosteroids help in septic shock.没有证据表明皮质类固醇对感染性休克有帮助。
Drug Ther Bull. 1990 Sep 17;28(19):74-5.
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Corticosteroids and septic shock: a new episode of a never-ceasing story?皮质类固醇与感染性休克：一个永不停歇的故事的新篇章？
Crit Care Med. 2008 May;36(5):1658-9. doi: 10.1097/CCM.0b013e31817045b3.
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Corticosteroids for septic shock--a standard of care?
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Use of corticosteroids in septic shock.脓毒性休克中糖皮质激素的应用。
Minerva Anestesiol. 2011 Feb;77(2):190-5. Epub 2010 Nov 24.
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本文引用的文献

1
Efficacy and safety of adjunctive corticosteroids in the treatment of severe community-acquired pneumonia: a systematic review and meta-analysis of randomized controlled trials.辅助性皮质类固醇治疗重症社区获得性肺炎的疗效和安全性：系统评价和随机对照试验的荟萃分析。
Crit Care. 2023 Jul 8;27(1):274. doi: 10.1186/s13054-023-04561-z.
2
ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia.ERS/ESICM/ESCMID/ALAT 指南：严重社区获得性肺炎管理。
Intensive Care Med. 2023 Jun;49(6):615-632. doi: 10.1007/s00134-023-07033-8. Epub 2023 Apr 4.
3
Hydrocortisone in Severe Community-Acquired Pneumonia.
严重社区获得性肺炎的氢化可的松治疗。
N Engl J Med. 2023 May 25;388(21):1931-1941. doi: 10.1056/NEJMoa2215145. Epub 2023 Mar 21.
4
Effect of Corticosteroids on Mortality and Clinical Cure in Community-Acquired Pneumonia: A Systematic Review, Meta-analysis, and Meta-regression of Randomized Control Trials.糖皮质激素对社区获得性肺炎病死率和临床治愈率的影响：一项随机对照试验的系统评价、荟萃分析和荟萃回归。
Chest. 2023 Mar;163(3):484-497. doi: 10.1016/j.chest.2022.08.2229. Epub 2022 Sep 7.
5
Low-dose methylprednisolone treatment in critically ill patients with severe community-acquired pneumonia.危重症社区获得性肺炎患者的小剂量甲基强的松龙治疗。
Intensive Care Med. 2022 Aug;48(8):1009-1023. doi: 10.1007/s00134-022-06684-3. Epub 2022 May 13.
6
Dexamethasone as risk-factor for ICU-acquired respiratory tract infections in severe COVID-19.地塞米松作为重症 COVID-19 患者 ICU 获得性呼吸道感染的危险因素。
J Crit Care. 2022 Jun;69:154014. doi: 10.1016/j.jcrc.2022.154014. Epub 2022 Feb 23.
7
Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial.地塞米松治疗急性呼吸窘迫综合征：一项多中心、随机对照试验。
Lancet Respir Med. 2020 Mar;8(3):267-276. doi: 10.1016/S2213-2600(19)30417-5. Epub 2020 Feb 7.
8
Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial.糖皮质激素对高炎症反应的住院重症社区获得性肺炎患者治疗失败的影响：一项随机临床试验。
JAMA. 2015 Feb 17;313(7):677-86. doi: 10.1001/jama.2015.88.
9
Steroids in sepsis: another swing of the pendulum in our clinical trials.脓毒症中的类固醇：我们临床试验中的又一次摇摆。
Crit Care. 2008;12(2):141. doi: 10.1186/cc6861. Epub 2008 Apr 29.
10
Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study.氢化可的松输注治疗重症社区获得性肺炎：一项初步随机研究。
Am J Respir Crit Care Med. 2005 Feb 1;171(3):242-8. doi: 10.1164/rccm.200406-808OC. Epub 2004 Nov 19.